纳布啡复合丙泊酚用于人工流产术的改良效果  

Improved efficacy of nalbuphine combined with propofol in artificial abortion

作　　者：贾丽[1] 张静[1] 邢玉英[1] 张艳红[1] 徐红萌[1] Jia Li;Zhang Jing;Xing Yuying;Zhang Yanhong;Xu Hongmeng(Department of Anesthesiology,Hebei Medical University Fourth Hospital,Shijiazhuang 050035,China)

机构地区：[1]河北医科大学第四医院麻醉科,石家庄050035

出　　处：《中华麻醉学杂志》2020年第2期210-212,共3页Chinese Journal of Anesthesiology

摘　　要：目的评价纳布啡复合丙泊酚用于人工流产术的改良效果。方法择期人工流产术患者100例,年龄20~43岁,体重50~80 kg,采用随机数字表法分为2组(n=50):丙泊酚组(P组)和纳布啡复合丙泊酚组(NP组)。术前15 min肌肉注射间苯三酚40 mg。P组静脉注射丙泊酚2.0 mg/kg;NP组静脉注射纳布啡0.1 mg/kg,2 min后静脉注射丙泊酚2.0 mg/kg。睫毛反射消失后开始手术。术中发生体动反应影响手术操作时追加丙泊酚0.5 mg/kg。采用VAS评估清醒时宫缩痛程度及恢复期间最高宫缩痛程度;记录丙泊酚用量、有关不良反应的发生情况及手术医师对麻醉效果的满意度。结果与P组比较,NP组丙泊酚用量减少,清醒时和恢复期间最高VAS评分降低,影响操作的体动反应发生率降低(16%/2%),手术医师对麻醉效果的满意度增高(P<0.05)。2组未见术中心血管不良事件、呼吸抑制及术后恶心、呕吐发生。结论静脉注射纳布啡0.1 mg/kg复合丙泊酚2.0 mg/kg可安全有效地用于人工流产术的舒适化医疗;与单纯丙泊酚相比,具有显著的优化作用。Objective To evaluate the improved efficacy of nalbuphine combined with propofol in artificial abortion.Methods One hundred American Society of Anesthesiologists physical statusⅠorⅡpatients,aged 20-43 yr,weighing 50-80 kg,undergoing elective artificial abortion,were divided into 2 groups(n=50 each)using a random number table method:propofol group(group P)and nalbuphine combined with propofol group(group NP).Phloroglucinol 40 mg was intramuscularly injected at 15 min before surgery.Propofol 2.0 mg/kg was intravenously injected in group P.In group NP,nalbuphine 0.1 mg/kg was intravenously injected,and 2 min later propofol 2.0 mg/kg was intravenously injected.The operation was started after the eyelash reflex disappeared.When operation was affected due to the body movement occurred during operation,an increment of propofol 0.5 mg/kg was given.Visual analogue scale(VAS)score was used to assess the degree of uterine contraction pain during the awake period and the highest degree of uterine contraction pain during the recovery period.The consumption of propofol,development of adverse effects and surgeon′s satisfaction with the anesthetic effect were recorded.Results Compared with group P,the consumption of propofol was significantly reduced,VAS scores during the awake period and the highest VAS score during the recovery period were decreased,the incidence of body movement that affected operation was decreased(16%/2%),and the surgeon′s satisfaction with the anesthetic effect was increased in group NP(P<0.05).No adverse cardiovascular events and respiratory depression during operation and postoperative nausea and vomiting was found in the two groups.Conclusion Intravenous injection of nalbuphine 0.1 mg/kg combined with propofol 2.0 mg/kg can be safely and effectively used for the comfort medical treatment of artificial abortion,and the combination has a significant optimized effect than propofol alone.

关 键 词：流产 人工 纳布啡 二异丙酚 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]