八段锦干预心力衰竭患者疗效的Meta分析  

Therapeutic Effects of Baduanjin on Patients with Heart Failure:A Meta-analysis

作　　者：王安铸 马晓昌[1] WANG Anzhu;MA Xiaochang(Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China)

机构地区：[1]中国中医科学院西苑医院,北京100091

出　　处：《世界中医药》2020年第13期1939-1945,1952,共8页World Chinese Medicine

基　　金：国家自然科学基金项目(81273932)。

摘　　要：目的:评估八段锦干预心力衰竭的疗效及安全性。方法:搜索中国知网数据库、中国生物医学文献数据库、万方数据库以及维普中文全文数据库;PubMed、Cochrane Library、web of science、EMBASE。检索时间为建库至2019年2月28日。对纳入的随机对照试验(RCT)用Cochrane手册进行偏倚风险评估,用Rev Man 5.3软件进行Meta分析。结果:纳入6篇文献,7个随机对照研究,共计543例心力衰竭患者。与对照组比较,观察组MLHFQ减少[MD=10.88,95%CI=(8.22,13.54)],6分钟步行试验(6MWT)提高[MD=107.81,95%CI=(75.83,139.78)],左心室射血分数(LVEF)提高[MD=3.62,95%CI=(2.04,5.19)],B型利钠肽(BNP)降低[MD=73.32,95%CI=(45.12,101.53)],临床疗效[OR=4.00,95%CI=(1.35,11.83)],中医证候评分[OR=4.57,95%CI=(2.03,10.31)]。结论:八段锦可改善心力衰竭患者的心功能,用于稳定期的康复治疗。Objective:To evaluate the therapeutic effects and safety of Baduanjin in the treatment of heart failure.Methods:The database of CNKI,Chinese biomedical literature database,Wanfang database,VIP full text database,PubMed,Cochrane Library,web of science,and EMBASE were searched.The time range for document retrieval was from the establishment of database to February 28th,2019.Risk of bias was assessed using the Cochrane manual for included RCT studies,and Meta-analysis was performed using Rev Man 5.3 software.Results:A total of 543 patients suffering heart failure were enrolled in 6 papers and 7 randomized controlled studies.Compared with the control group,the treatment group reduced MLHFQ[MD=10.88,95%CI=(8.22,13.54)];6 WMT distance improved[MD=107.81,95%CI=(75.83,139.78)];LVEF improved[MD=3.62,95%CI=(2.04,5.19)];BNP improved[MD=73.32,95%CI=(45.12,101.53)];clinical efficacy[OR=4.00,95%CI=(1.35,11.83)],TCM syndrome scores[OR=4.57,95%CI=(2.03,10.31)].Conclusion:Baduanjin can improve the cardiac function of patients with heart failure and is used for stable rehabilitation treatment.

关 键 词：八段锦 心力衰竭 明尼苏达生命质量问卷 6分钟步行试验 左心室射血分数 B型利钠肽 N-末端B型利钠肽原 META分析 

分 类 号：R247.9[医药卫生—中医临床基础] R541.4[医药卫生—中医学]