吴茱萸次碱通过调控表皮生长因子受体活化抑制高血压心肌肥大  

Rutaecarpine against hypertensive cardiac hypertrophy via inhibiting epidermal growth factor receptor activation

作　　者：严秋江 范秀晶 杨妍[2] 杨水源[2] 梁金成[2] 曾泗宇[2] YAN Qiujiang;FAN Xiujing;YANG Yan;YANG Shuiyuan;LIANG Jincheng;ZENG Siyu(Cardiology Zone Ⅱ of Department of Cardiothoracic Surgery,the Third Affiliated Hospital of Guangzhou Medical University,Guangzhou 510000,Guangdong,China;Department of Pharmacy,Guangdong Second Provincial General Hospital,Guangzhou 510000,Guangdong,China)

机构地区：[1]广州医科大学附属第三医院心胸外科心内二区,广东广州510000 [2]广东省第二人民医院药学部,广东广州510317

出　　处：《中南医学科学杂志》2020年第4期349-355,共7页Medical Science Journal of Central South China

基　　金：广东省科技计划项目(2016A020226005);广东省自然科学基金项目(2015A030310076).

摘　　要：探讨抑制表皮生长因子受体(EGFR)活化是否调控中药单体药吴茱萸次碱的抗高血压心肌肥大效应及其机理。以腹主动脉缩窄(AAC)介导的高血压大鼠为研究对象,观察吴茱萸次碱对高血压心肌肥大、心肌炎症反应以及左心室中EGFR和细胞外调节蛋白激酶1/2(ERK1/2)活性的影响。结果显示,吴茱萸次碱能显著抑制AAC介导的高血压心肌肥大、心肌炎症反应以及EGFR、ERK1/2活化。并且,选择性EGFR抑制剂AG1478能改善AAC介导的高血压心肌肥大和心肌炎症反应,抑制ERK1/2活化。结果提示,吴茱萸次碱通过抑制EGFR活化改善AAC介导的高血压大鼠心肌肥大,其机制与其抑制ERK1/2活化和心肌炎症反应有关。To explore whether inhibiting epidermal growth factor receptor(EGFR)regulates the beneficial role of rutaecarpine in hypertensive cardiac hypertrophy.Abdominal artery constriction(AAC)-induced hypertensive rats were adopted to explore the effects of rutaecarpine on hypertensive cardiac hypertrophy,cardiac inflammation,and the activity of EGFR and extracellular signal regulated kinase(ERK1/2).Results indicated that rutaecarpine significantly attenuated hypertensive cardiac hypertrophy and cardiac inflammation,as well as the activity of EGFR and ERK1/2 in the left ventricle of AAC-induced hypertensive rats.Moreover,treating with selective EGFR inhibitor AG1478 alleviated hypertensive cardiac hypertrophy and cardiac inflammation,and it caused a marked reduction in ERK1/2 activity in the left ventricle of AAC-induced hypertensive rats.In summary,rutaecarpine improves hypertensive cardiac hypertrophy through inhibition of EGFR activation via inhibiting ERK1/2 activity and cardiac inflammation.

关 键 词：吴茱萸次碱 高血压心肌肥大 表皮生长因子受体 炎症反应 细胞外调节蛋白激酶1/2 

分 类 号：R544.1[医药卫生—心血管疾病]