树突棘与神经相关疾病  

DENDRITIC SPINES AND NERVOUS ASSOCIATED DISEASES

作　　者：薛华 马英杰 赵东芹[1] Xue Hua;Ma Yingjie;Zhao Dongqin(Shandong Provincial Key Laboratory of Animal Resistance Biology,School of Life Science,Shandong Normal University,250014,Jinan,China)

机构地区：[1]山东师范大学生命科学学院,山东省动物抗性生物学重点实验室,济南250014

出　　处：《山东师范大学学报（自然科学版）》2020年第2期232-235,共4页Journal of Shandong Normal University(Natural Science)

基　　金：国家自然科学基金资助项目(31501861);山东省自然科学基金资助项目(ZR2015CM013).

摘　　要：树突棘是形成突触的关键部位,阿尔茨海默症、帕金森病、癫痫、缺血性脑中风、抑郁症等神经相关疾病都表现出树突棘形态、密度的改变,进而影响突触功能,改变树突棘形态已成为疾病治疗的一个新研究方向.本文就树突棘在各类神经相关疾病中的改变及其可能的调控机制、主要靶点分子等研究内容进行综述.Dendritic spines are the key part of synapses.The shapes and densities of dendritic spines are shown to be changed in nervous related diseases such as alzheimer′s,Parkinson′s disease,epilepsy,ischemic stroke,depression,which in turn affects the functions of synapses.Changing the dendritic spines has now become a new research direction of the diseases.In this paper,researches on the changes of dendritic spines in those kinds of nervous related diseases and the possible regulation mechanisms as well as the main target molecules are summarized.

关 键 词：树突棘 突触可塑性 神经性疾病 

分 类 号：Q42[生物学—神经生物学]