巴曲酶联合银杏叶提取物注射液治疗突发性聋的临床随机对照试验Meta分析  

Meta-analysis of clinical randomized control study of batroxobin combined with ginkgo biloba extract injection treating sudden deafness

作　　者：黄学勤[1] 赵萍[2] 武玲 查大慧 洪飞[1] HUANG Xueqin;ZHAO Ping;WU Ling;ZHA Dahui;HONG Fei(Department of Otolaryngology,The Third Clinical College of Anhui Medical University(The Third People’s Hospital of Hefei),Hefei,Anhui 230022,China;Department of Nursing,The Third Clinical College of Anhui Medical University(The Third People’s Hospital of Hefei),Hefei,Anhui 230022,China)

机构地区：[1]安徽医科大学合肥第三临床学院、合肥市第三人民医院,耳鼻喉科,安徽合肥230022 [2]安徽医科大学合肥第三临床学院、合肥市第三人民医院,护理部,安徽合肥230022

出　　处：《安徽医药》2020年第8期1494-1497,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的评价巴曲酶联合银杏叶提取物注射液治疗突发性聋的临床疗效,为临床的推广应用提供依据。方法计算机检索中国知网、万方、维普、中国生物医学文献数据库收录的有关巴曲酶和银杏叶提取物注射液联合治疗突发性聋的临床效果分析的文章,检索年限从建库至2019年4月。根据纳入和排除标准纳入文献及提取资料,采用Rev Man 5.3软件进行Meta分析。纳入Meta分析的文献共13篇,均为临床随机对照治疗研究,包含1 274个研究对象,比较联合用药的观察组与单一用药的对照组突发性聋的总有效率。结果两组治疗突发性聋的疗效比较,差异有统计学意义(RR=1.21,95%CI:1.15~1.27,Z=7.64,P<0.01)。结论使用巴曲酶联合银杏叶提取物注射液治疗突发性聋疗效显著,值得在临床中推广应用。Objective To evaluate the clinical efficacy of batroxobin combined with ginkgo biloba extract injection in the treatment of sudden deafness,and provide a basis for clinical application.Methods Computers were searched for articles on the clinical effects of Batroxobin and Ginkgo biloba extract injections in the treatment of sudden deafness,which were included in the China Knowledge Network,Wanfang,Weipu,and China Biomedical Literature Database.The search period is from the establishment of the library to April 2019.Meta-analysis was performed using Rev Man 5.3 software based on inclusion and exclusion criteria for inclusion in the literature and extraction of data.A total of 13 articles included in the Meta-analysis were randomized controlled trials,including 1274 subjects.The total effective rate of sudden deafness was compared between the observation group and the single-drug control group.Results There was a statistically significant difference between the two groups in the treatment of curative effect of sudden deafness(RR=1.21,95%CI:1.15-1.27,Z=7.64,P<0.01).Conclusion The use of batroxobin combined with ginkgo biloba extract injection for the treatment of sudden deafness has significant efficacy and is worthy of popularization and application in clinical practice.

关 键 词：听觉丧失 突发性/药物疗法 巴曲酶 银杏叶提取物 META分析 

分 类 号：R764.437[医药卫生—耳鼻咽喉科]