妊娠期糖尿病母亲葡萄糖耐量试验不同时点血糖水平与新生儿体格发育相关性分析  

Correlation analysis of blood glucose level and neonate physical growth at different time points of OGTT in GDM

作　　者：胡敏 朱贝贝 HU Min;ZHU Beibei(Department of Neonatology,Ma’anshan Maternal and Children Health Hospital,Ma’anshan,Anhui 243000,China;School of Public Health,Anhui Medical University,Hefei,Anhui 230032,China)

机构地区：[1]马鞍山市妇幼保健院新生儿科,安徽马鞍山243000 [2]安徽医科大学公共卫生学院,安徽合肥230032

出　　处：《安徽医药》2020年第8期1518-1520,共3页Anhui Medical and Pharmaceutical Journal

基　　金：国家自然科学基金资助项目(81602866)。

摘　　要：目的描述妊娠期糖尿病(GDM)母亲口服糖耐量(OGTT)不同时点血糖值与新生儿体格发育相关性,为GDM规范诊断提供依据。方法选取2019年1-11月在马鞍山市妇幼保健院住院的新生儿84例,均母亲诊断为GDM,回顾母亲孕期OGTT不同时点血糖值,根据单项血糖指标异常及异常指标数分组,比较不同组间包括体质量、身长、头围、皮下脂肪等体格发育指标分布差异性,对有相关性的指标进行多元线性回归分析。结果空腹血糖(FPG)、服糖后1 h血糖(1 h PG)以及服糖2 h血糖(2 h PG)异常发生率分别为78.3%、85.7%和79.8%。仅1 h PG组体质量、头围均数分布差异有统计意义,异常组高于对照组。在调整胎龄后,多元线性回归分析1 h PG与头围存在显著正相关,β值为1.04(95%CI:0.15~1.93)。结论母亲OGTT不同时点血糖值与新生儿体格发育相关性存在差异,在GDM诊断时应重视每一项指标的异常,及时诊断和有效干预。Objective To describe the relationship between blood glucose and physical development of neonates at different time points of oral glucose tolerance test(OGTT)in gestational diabetes mellitus(GDM),so as to provide a basis for the standard diagnosis of GDM.Methods Eighty-four neonates in Ma’anshan Maternal and Children Health Hospital from January to November2019 were selected and their mothers were diagnosed as GDM.The blood glucose values at different time points of OGTT were reviewed.Neonates were assigned in different groups according to the abnormal single blood glucose index and the number of abnormal index.The differences in the distribution of physical development indexes including body weight,body length,head circumference and subcutaneous fat between different groups were compared,and the related indexes were analyzed by multiple linear regression analysis.Results The incidence of FPG,1 h PG and 2 h PG was 78.3%,85.7% and 79.8%,respectively.Only the distribution difference of body weight and head circumference in 1 h PG group was statistically significant,and body weight and head circumference of the abnormal group were higher than that of the control group.After adjusted the gestational age,multiple linear regression analysis showed that there was a significant positive correlation between 1 h PG and head circumference,β value was 1.04(95%CI:0.15-1.93).Conclusion There are differences in the correlation between blood glucose and physical development of newborn at different time points of OGTT.We should pay attention to the abnormality of each index in the diagnosis of GDM,and make timely diagnosis and effective intervention.

关 键 词：糖尿病 妊娠 身高 出生体质量 皮下脂肪 口服糖耐量试验 新生儿 

分 类 号：R714.256[医药卫生—妇产科学]