基于logistic回归模型的前列地尔注射液引起静脉炎危险因素分析  

Analysis of risk factors of alprostadil injection induced phlebitis based on logistics regression model

作　　者：张冬燕[1] 齐艳霞[1] 马培志[1] ZHANG Dongyan;QI Yanxia;MA Peizhi(Department of Pharmacy,Henan Provincial People’s Hospital,Zhengzhou,Henan 450003,China)

机构地区：[1]河南省人民医院药学部,河南郑州450003

出　　处：《安徽医药》2020年第8期1663-1665,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的研究前列地尔注射液发生静脉炎相关的危险因素,为临床应用中减少静脉炎的发生提供参考。方法收集2018年1-12月河南省人民医院输注前列地尔注射液发生静脉炎的所有病历共29份作为试验组,收集364例同期输注前列地尔的无静脉炎的住院病人作为对照组,对致静脉炎的可能危险因素进行单因素分析及多因素非条件logistic回归分析。结果单因素分析及多因素非条件二元logistic回归分析结果均显示,病人过敏史、用药剂量、溶媒体积3个因素在试验组与对照组之间的差异有统计学意义(P<0.05),是前列地尔注射液引起静脉炎的独立危险因素。结论临床使用前列地尔注射液时,应加强过敏史、用药剂量、溶媒体积等危险因素的用药管理,规范使用,减少不必要的静脉炎发生。Objective To investigate related risk factors of alprostadil injection induced phlebitis,and provide a reference for the prevention of the reaction.Methods Totally 29 clinical medical records of alprostadil injection induced phlebitis in Henan Provincial People’s Hospital from January to December 2018 were collected as experimental group;364 medical records without alprostadil injection induced phlebitis during the same period were included as control group.The single factor analysis and multivariate logistic regression analysis were conducted for the potential risk factors.Results Results of single factor analysis and multivariate logistic regression analysis showed that there was statistical significance in 3 factors including the history of allergy,dosage and solvent volume between experimental group and control group(P<0.05),and they were independent risk factors to alprostadil injection induced phlebitis.Conclusion During the clinical application of alprostadil injection,great importance should be attached for the risk factors,including history of allergy,dosage and solvent volume,so as to prevent unnecessary allergic reactions effectively.

关 键 词：前列地尔/副作用 静脉炎 危险因素 LOGISTIC回归 

分 类 号：R543.6[医药卫生—心血管疾病]