某医院2016-2019年造影剂相关不良反应77例分析  

Retrospective analysis of 77 cases of adverse drug reactions induced by contrast agent in a hospital from 2016 to 2019

作　　者：李海燕[1] 王惠川[2] 闵慧[1] 薛小荣[1] LI Haiyan;WANG Huichuan;MIN Hui;XUE Xiaorong(Department of Pharmacy,Xi’an Fourth Hospital,Xi’an,Shaanxi 710004,China;Health Management Center,Xi’an Fourth Hospital,Xi’an,Shaanxi 710004,China)

机构地区：[1]西安市第四医院药剂科,陕西西安710004 [2]西安市第四医院健康管理中心,陕西西安710004

出　　处：《安徽医药》2020年第8期1689-1692,共4页Anhui Medical and Pharmaceutical Journal

基　　金：陕西省重点研发计划项目(2018SF-319);西安市第四医院科研孵化基金-2018年度学科发展科技支持项目(FZ-19)

摘　　要：目的分析造影剂在临床应用中不良反应的发生特点,为临床合理使用造影剂提供参考。方法回顾性分析西安市第四医院2016年1月至2019年12月上报的造影剂相关不良反应(ADR)报告表,分析ADR病人的年龄、性别、严重程度、疾病分布、ADR的发生时间,累及系统/器官及主要临床表现,ADR的处理及结果等。结果造影剂相关不良反应报告共77例,其中3例为严重不良反应。共涉及造影剂5个品种,居前3位的分别为碘海醇、碘佛醇及钆喷酸葡胺。>50~70岁年龄组ADR发生比例较高,占比为58.44%。药品不良反应主要发生在试敏(6例,85.71%)和给药后10 min以内(31例,49.21%),临床表现以皮肤及附件损害所占比例最大(43例,34.13%)、其次为消化系统损害(23例,18.25%),第三为循环系统损害(21例,16.67%)。结论造影剂在临床使用时应加强对其用药风险评估及相关ADR的主动监测,确保临床用药安全。Objective To analyze problems of contrast agents used in clinic and the characteristics of contrast agent adverse drug reactions(ADRs),and provide a reference for rational use of contras agents.Methods The adverse drug reaction(ADR)reports of contrast agents in the Fourth Hospital of Xi’an from January 2016 to December 2018 were retrospectively analyzed.The gender,age,severity,distribution of disease,occurrence time,affecting system and organs,main clinical manifestations,and ADR processing and results of ADR-related patients were analyzed.Results A total of 77 cases of contrast agent-induced ADRs,which were 3 cases of severe ADRs.The 77 cases of ADR involved 5 varieties of contrast agent,the top three were iohexol,ioversol and gadopentetate dimeglumine.The proportion of contrast agent-induced ADR was significantly higher in the group of>50-70 years of age,which was 58.44%.The ADR mainly occurred in skin test(6 cases,85.71%)and 10 minutes after medication(31 cases,49.21%),and the clinical manifestations was skin and local lesion(43 cases,34.13%),followed by gastro-intestinal damage(23 cases,18.25%)and circulation system damage(21 cases,16.67%).Conclusion In the clinical use of contrast agents,it is necessary to strengthen the risk assessment of contrast agents and the monitoring of related ADR to ensure the safety of clinical medication.

关 键 词：造影剂/副作用 过敏反应 不良反应 用药安全 

分 类 号：R981[医药卫生—药品]