输尿管软镜碎石术对直径小于2cm的肾结石患者应激反应及炎症指标的影响  

Influence of ureteroscopic lithotripsy on stress response and inflammatory indexes in patients with renal stone less than 2cm

作　　者：周青[1] 舒畅[1] 朱云海[1] 杨波[1] 孟军[1] 马勇 曾志[1] ZHOU Qing;SHU Chang;ZHU Yunhai;YANG Bo;MENG Jun;MA Yong;ZENG Zhi(Department of Urinary Surgery,Baoshan Branch of Shanghai First People′s Hospital,Shanghai,200940)

机构地区：[1]上海市第一人民医院宝山分院泌尿外科,上海200940

出　　处：《实用临床医药杂志》2020年第8期33-35,共3页Journal of Clinical Medicine in Practice

摘　　要：目的探讨输尿管软镜碎石术对直径小于2 cm的肾结石患者应激反应及炎症指标的影响。方法选取78例直径小于2 cm的肾结石患者,随机分为对照组和观察组各39例。对照组采用经皮肾镜碎石术,观察组采用输尿管软镜碎石术。比较2组应激反应指标及炎症反应指标水平。结果2组术后去甲肾上腺素(NE)及肾上腺素(E)水平均较术前显著降低,且观察组显著低于对照组(P<0.05);2组术后白细胞介素-6(IL-6)及白细胞介素-10(IL-10)水平均较术前显著升高,但观察组显著低于对照组(P<0.05)。结论对直径小于2 cm的肾结石患者采用输尿管软镜碎石术治疗安全、有效,可缓解患者应激反应程度,控制炎症因子水平。Objective To investigate the influence of ureteroscopic lithotripsy on stress response and inflammatory indexes in patients with renal stone less than 2 cm.Methods Totally 78 patients with renal stone less than 2 cm were selected and randomly divided into control group(n=39)and observation group(n=39).The control group was treated with percutaneous nephrolithotripsy,and the observation group was treated with ureteroscopic lithotripsy.The levels of stress response indexes and inflammatory response indexes were compared between the two groups.Results The levels of norepinephrine(NE)and epinephrine(E)after operation in both group were significantly lower than those before operation,and the indexes in observation group were significantly lower than control group(P<0.05).After operation,the levels of interleukin-6(IL-6)and interleukin-10(IL-10)in both groups were significantly higher than those before operation,and these indexes in observation group were significantly lower than control group(P<0.05).Conclusion Ureteroscopic lithotripsy is safe and effective in the treatment of patients with renal stone less than 2 cm,which can alleviate the degree of stress response and control the levels of inflammatory factors.

关 键 词：肾结石 输尿管软镜碎石术 经皮肾镜碎石术 应激反应 炎症反应 去甲肾上腺素 肾上腺素 白细胞介素 

分 类 号：R692.4[医药卫生—泌尿科学]