未分化关节炎患者血清Ⅰ型胶原吡啶交联终肽、抗环瓜氨酸肽抗体及类风湿因子水平及临床意义  

Levels and clinical significance of serum pyridinoline cross-linked carboxyterminal telopeptide of typeⅠcollagen,anti-cyclic citrullinated peptide antibody and rheumatoid factor in patients with undifferentiated arthritis

作　　者：刘玮 郭苗 赵文娜[2] 李伟 LIU Wei;GUO Miao;ZHAO Wenna;LI Wei(Department of Clinical Laboratory,Baoji High-tech People′s Hospital,Baoji,Shaanxi,721000;Baoji Maternal and Child Health Care Hospital,Baoji,Shaanxi,721000)

机构地区：[1]陕西省宝鸡高新人民医院检验科,陕西宝鸡721000 [2]陕西省宝鸡市妇幼保健院,陕西宝鸡721000

出　　处：《实用临床医药杂志》2020年第8期82-85,共4页Journal of Clinical Medicine in Practice

基　　金：陕西省卫生厅科研基金项目(2016SG873510)。

摘　　要：目的探讨未分化关节炎(UA)患者血清Ⅰ型胶原吡啶交联终肽(ICTP)、抗环瓜氨酸肽(CCP)抗体及类风湿因子(RF)水平。方法选取60例UA患者为UA组,另选取同期健康体检者32名为对照组。比较UA组和对照组入院时血清ICTP、抗CCP抗体及RF水平。分析血清ICTP、抗CCP抗体及RF水平预测UA进展为类风湿性关节炎(RA)的价值。结果UA组血清ICTP、抗CCP抗体及RF水平显著高于对照组(P<0.05)。Pearson相关性分析显示,血清ICTP与抗CCP抗体呈显著正相关(r=0.613,P<0.05),血清ICTP与RF呈显著正相关(r=0.438,P<0.05),血清抗CCP抗体与RF呈显著正相关(r=0.452,P<0.05)。受试者工作特征(ROC)曲线分析结果显示,血清ICTP、抗CCP抗体及RF水平预测UA进展为RA的最佳截断值分别为4.52μg/L、20.84 U/mL和18.50 U/mL。血清ICTP、抗CCP抗体及RF水平联合预测的曲线下面积(AUC)显著高于RF单项(Z=2.573,P=0.010)。结论血清ICTP、抗CCP抗体及RF水平在预测UA进展为RA中均有一定的价值,联合检测对于早期预测UA转归具有重要意义。Objective To explore the levels of serum pyridinoline cross-linked carboxyterminal telopeptide of typeⅠcollagen(ICTP),anti-cyclic citrullinated peptide(CCP)antibody and rheumatoid factors(RF)in patients with undifferentiated arthritis(UA).Methods Totally 60 UA patients were selected as UA group,and 32 healthy people with physical examination were selected as control group.The levels of serum ICTP,anti-CCP antibody and RF were compared between UA group and control group.The values of serum ICTP,anti-CCP antibody and RF levels in predicting the progression of UA to rheumatoid arthritis(RA)was analyzed.Results The levels of serum ICTP,anti-CCP antibody and RF in UA group were significantly higher than those in control group(P<0.05).Pearson correlation analysis showed that there was a significant positive correlation between serum ICTP and anti-CCP antibody(r=0.613,P<0.05),a significant positive correlation between serum ICTP and RF(r=0.438,P<0.05),and a significant positive correlation between serum anti-CCP antibody and RF(r=0.452,P<0.05).The results of Receiver Operating Characteristic(ROC)curve analysis showed that the best cut-off values of ICTP,anti-CCP antibody and RF in predicting the progression of UA to RA were 4.52μg/L,20.84 U/mL and 18.50 U/mL respectively.The area under the curve(AUC)predicted by combination of serum ICTP,anti-CCP antibody and RF levels was significantly higher than that by RF(Z=2.573,P=0.010).Conclusion The levels of serum ICTP,anti-CCP antibody and RF have certain values in predicting the progression of UA to RA,and the combined detection of the three indexes shows great significance for the early prediction of the outcome of UA.

关 键 词：未分化关节炎 Ⅰ型胶原吡啶交联终肽 抗环瓜氨酸肽抗体 类风湿因子 类风湿性关节炎 

分 类 号：R684.3[医药卫生—骨科学]