非编码RNA在类风湿关节炎中的研究进展  

Research Progress of Non-coding RNA in Rheumatoid Arthritis

作　　者：陈宇婷 李琼[1] 隋础阳 接力刚 毋静[1] 杜红延 CHEN Yuting;LI Qiong;SUI Chuyang;JIE Ligang;WU Jing;DU Hongyan(First College of Clinical Medicine,Southern Medical University,Guangzhou,Guangdong,China,510515;School of Laboratory Medicine and Biotechnology,Southern Medical University,Guangzhou,Guangdong,China,510515;Department of Rheumatology and Clinical Immunology,Zhujiang Hospital,Southern Medical University,Guangzhou,Guangdong,China,510282)

机构地区：[1]南方医科大学第一临床医学院,广东广州510515 [2]南方医科大学第二临床医学院(珠江医院)风湿免疫科,广东广州510282 [3]南方医科大学检验与生物技术学院,广东广州510515

出　　处：《分子诊断与治疗杂志》2020年第7期974-977,986,共5页Journal of Molecular Diagnostics and Therapy

基　　金：国家自然科学基金(81601397,81102688);广东省自然科学基金(2016A030313624)。

摘　　要：随着研究的深入,基因表达过程所受的关注已不仅仅局限在"DNA-mRNA-蛋白质".长久以来被忽略的非编码RNA(non-coding RNA,nc RNA)在基因表达过程中所发挥的调控作用逐渐被发现,其广泛参与人体生理、病理过程的调节.类风湿关节炎(RA)是一种自身免疫性疾病,影响其发生发展的因素很多,目前尚未明确,但越来越多的研究发现部分非编码RNA在RA发病过程中出现差异表达并产生显著影响.本篇综述主要总结了近年来研究发现的在RA中表达异常的微小RNA(miRNA)、长链非编码RNA(lncRNA)、环状RNA(circRNA)以及它们参与RA可能的调控机制.With the deepening of research,the attention that the gene expression process has received is not limited to"DNA-mRNA-protein". The long-neglected non-coding RNA(ncRNA)played a regulatory role in the gene expression process,which was gradually discovered,and widely involved in the regulation of human physiological and pathological processes. Rheumatoid arthritis(RA)is an autoimmune disease. The factors that affect RAs pathogenesis and development remain unclear. However,more and more studies have found that some ncRNAs are differentially expressed during the pathogenesis of RA and have significant impact.This review summarizes the microRNAs(miRNAs),long noncoding RNAs(lncRNAs)and circular RNAs(circRNAs)that have been differentially expressed in RA and their possible regulatory mechanisms in recent studies.

关 键 词：非编码RNA 微小RNA 长链非编码RNA 环状RNA 类风湿关节炎 

分 类 号：R593.22[医药卫生—内科学]