二甲双胍联合厄贝沙坦治疗糖尿病合并高尿酸血症的效果  

Effect of Metformin combined with Irbesartan on clinical symptoms and serum uric acid level in patients with diabetes mellitus complicated with hyperuricemia

作　　者：冯召岚[1] FENG Zhao-lan(Department of Endocrinology,the First People′s Hospital of Jiujiang City,Jiangxi Province,Jiujiang332000,China)

机构地区：[1]江西省九江市第一人民医院内分泌科,江西九江332000

出　　处：《中国当代医药》2020年第20期34-36,共3页China Modern Medicine

基　　金：江西省卫生计生委科技计划项目(20157075)。

摘　　要：目的探讨二甲双胍联合厄贝沙坦治疗糖尿病合并高尿酸血症的效果。方法选取我院2017年1月~2019年8月接收的80例糖尿病合并高尿酸血症患者作为研究对象,通过随机数字表法分为对照组和实验组,各40例。对照组在常规治疗基础上给予二甲双胍治疗,实验组在对照组基础上联合使用厄贝沙坦治疗。对比两组血糖指标、胰岛素抵抗指数、体重指数变化、血清尿酸水平情况。结果治疗后,实验组空腹血糖、餐后2 h血糖、糖化血红蛋白水平低于对照组,差异均有统计学意义(P<0.05);治疗后,实验组胰岛素抵抗指数、体重指数及血清尿酸水平均低于对照组,差异有统计学意义(P<0.05)。结论二甲双胍联合厄贝沙坦能够降低糖尿病合并高尿酸血症患者体重指数,纠正胰岛素抵抗,调节血糖代谢,降低血清尿酸水平。Objective To explore the effect of Metformin combined with Irbesartan in the treatment of diabetes with hyperuricemia.Methods A tatal of 80 patients with diabetes and hyperuricemia received in our hospital from January 2017 to August 2019 were selected as the research object and divided into control group and experimental group by the random number table method,each with 40 cases.The control group accepted Metformin on the basis of conventional treatment,and the experimental group accepted Irbesartan in combination with the control group.The blood glucose index,insulin resistance index,body mass index changes,and serum uric acid levels were compared between the two groups.Results After treatment,the fasting blood glucose,2 h postprandial blood glucose,and glycated hemoglobin levels in the experimental group were lower than those in the control group(P<0.05);after treatment,the insulin resistance index,body mass index,and serum uric acid levels in the experimental group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion Metformin combined with Irbesartan can reduce the body mass index of patients with diabetes and hyperuricemia,correct insulin resistance,regulate blood glucose metabolism,and reduce serum uric acid levels.

关 键 词：糖尿病 高尿酸血症 厄贝沙坦 二甲双胍 血糖指标 尿酸水平 

分 类 号：R587[医药卫生—内分泌]