达格列净联合利拉鲁肽治疗2型糖尿病的效果  

Effect of Dapagliflozin combined with Liraglutide in the treatment of type 2 diabetes mellitus

作　　者：王丹 谷晓岚 田雨 WANG Dan;GU Xiao-lan;TIAN Yu(Department of Endocrinology,Dalian Municipal Central Hospital Affilliated to Dalian Medical University,Liaoning Province,Dalian116033,China;Department of Anesthesiology,Dalian Municipal Central Hospital Affilliated to Dalian Medical University,Liaoning Province,Dalian116033,China)

机构地区：[1]大连医科大学附属大连市中心医院内分泌科,辽宁大连116033 [2]大连医科大学附属大连市中心医院麻醉科,辽宁大连116033

出　　处：《中国当代医药》2020年第20期69-72,共4页China Modern Medicine

摘　　要：目的探讨达格列净联合利拉鲁肽治疗2型糖尿病的效果。方法选择2017年1月~2018年10月本院收治的80例2型糖尿病患者为研究对象,按照随机数字表法分为观察组(40例)与对照组(40例)。对照组使用利拉鲁肽,观察组在对照组的基础上早餐前口服达格列净。比较两组干预前后的血糖代谢指标[空腹血糖、餐后2 h血糖、糖化血红蛋白(HbA1c)及胰岛素抵抗指数稳态模型(HOMA-IR)]、血脂代谢指标[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇(HDL-C)]、体重指数(BMI),随访1年,统计两组的并发症发生情况。结果观察组干预后血糖代谢指标中的空腹血糖、餐后2 h血糖、HbA1c及胰岛素抵抗指数(HOMA-IR)水平均低于对照组,差异有统计学意义(P<0.05);观察组干预后血脂代谢指标中的TC、TG、LDL-C水平均低于对照组,HDL-C水平高于对照组,差异有统计学意义(P<0.05)。观察组干预后的BMI低于干预前及对照组干预后,差异有统计学意义(P<0.05)。随访1年期间,观察组的糖尿病足、视网膜病变、周围神经病变及糖尿病肾病发生率均低于对照组,差异有统计学意义(P<0.05)。结论针对2型糖尿病,在应用利拉鲁肽基础上联合使用达格列净能更好地调节血糖、血脂代谢及机体体质状况,减少或延缓并发症发生。Objective To investigate the effect of Dapagliflozin combined with Liraglutide in the treatment of type 2 diabetes mellitus.Methods A total of 80 cases with type 2 diabetes mellitus from January 2017 to October 2018 in our hospital were selected as the research objects,and were divided into the observation group(40 cases)and the control group(40 cases)according to the random number table method.The control group was treated with Liraglutide,the observation group was treated with Dapagliflozin before breakfast on the basis of the control group.The blood glucose metabolic indexes(such as abdominal blood glucose,blood glucose 2 hours after meal,HbA1c and HOMA-IR changes),the metabolic indexes of blood lipid(such as total cholesterol[TC],triglyceride[TG],low density lipoprotein[LDL-C]and high density lipoprotein[HDL-C]),the changes of body mass index(BMI)in the two groups before and after intervention were compared.The complications of the two groups were analyzed after one year follow-up.Results The levels of fasting blood glucose,2-hour postprandial blood glucose,HbA1c and HOMA-IR in the blood glucose metabolic indexes in the observation group after intervention were lower than those in the control group,the differences were statistically significant(P<0.05).The levels of TC,TG and LDL-C in blood lipid metabolic indexes in the observation group after intervention were lower than those in the control group,the levels of HDL-C in the observation group after intervention was higher than control group,the differences were statistically significant(P<0.05).After intervention,the BMI in the observation group was lower than before intervention and in the control group after intervention,the differences were statistically significant(P<0.05).During the follow-up period of one year,the incidence of diabetic foot,retinopathy,peripheral neuropathy and diabetic nephropathy in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion The combination of Lir

关 键 词：达格列净 利拉鲁肽 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]