溶瘤病毒治疗犬类癌症的研究进展  

Progress Oncolytic Virus in Treatment of Canine Cancer

作　　者：任晓丽 范玉营 和昭弟 张磊[1] 石冬梅[1] 刘云[2] REN Xiao-li;FAN Yu-ying;HE Zhao-di;ZHANG Lei;SHI Dong-mei;LIU Yun(College of Veterinary Medicine,Henan University of Animal Husbandry of Economy,Zhengzhou,Henan,450046,China;College of Veterinary Medicine,Northeast Agricultural University,Harbin,Heilongjiang,150030,China)

机构地区：[1]河南牧业经济学院动物医药学院,河南郑州450046 [2]东北农业大学动物医学学院,黑龙江哈尔滨150036

出　　处：《动物医学进展》2020年第8期108-112,共5页Progress In Veterinary Medicine

基　　金：河南牧业经济学院院级重点培育学科建设项目(41000002);河南省高等学校重点项目(20B230004);十三五国家重点研发项目(2016YFD0501008);河南牧业经济学院博士科研启动基金(906/24030107)。

摘　　要：溶瘤病毒疗法是一种有前景的癌症治疗新策略。溶瘤病毒治疗主要依赖于非致病性病毒株的参与,在原发和转移肿瘤细胞中表现出选择性的病毒复制,造成细胞病理反应和特异性免疫反应,从而导致肿瘤细胞的裂解死亡,同时对正常细胞和组织却没有破坏作用或影响较小。已有大量研究对天然病毒和基因改造病毒(如腺病毒、犬瘟热病毒、呼肠病毒、牛痘病毒及重组病毒等)的溶瘤机制、给药途径、治疗效果及安全性等方面进行了广泛探讨。论文综述溶瘤病毒在治疗犬类癌症中常用的病毒种类,分析溶瘤病毒在肿瘤治疗中的研究现状,将有助于溶瘤病毒在犬类癌症治疗中的制剂开发。Oncolytic virus therapy is a promising new strategy for cancer treatment.It relies on the involvement of non-pathogenic viral strains which show selective viral replication in primary and metastatic tumor cells.The viruses thus lead to cell pathological response and tumor-specific immune response,and cause cancer cell lysis and death,but has no damage or little impact on normal cells and tissues.Numerous studies have investigated the oncolysis mechanism,administration route,therapeutic effect and safety of natural virus and genetically modified virus(such as adenovirus,canine distemper virus,reovirus,vaccinia virus and recombinant virus,etc.).In this paper,we reviewed the common types of oncolytic viruses,and analyzed the research status of oncolytic viruses in the treatment of canine cancer,which will contribute to the development of oncolytic viruses agents in the treatment of canine cancer.

关 键 词：溶瘤病毒 癌症 犬 

分 类 号：S854.59[农业科学—临床兽医学] S858.292[农业科学—兽医学]