双歧杆菌四联活菌片辅助治疗对新诊断2型糖尿病患者血清炎症因子及氧化应激指标水平的调节作用  

Regulatory effect of Tetragenous Viable Bifidobacterium Tablets adjuvant therapy on serum inflammatory factors and oxidative stress in newly diagnosed type 2 diabetic patients

作　　者：吴晓晔 WU Xiaoye(Department of Medicine,Jiaxing Nanhu District Central Hospital,Jiaxring,Zhejiang 314000,China)

机构地区：[1]嘉兴市南湖区中心医院内科,浙江嘉兴314000

出　　处：《中国微生态学杂志》2020年第6期680-683,共4页Chinese Journal of Microecology

摘　　要：目的探讨双歧杆菌四联活菌片辅助治疗对新诊断2型糖尿病(T2DM)患者血清炎症因子及氧化应激指标水平的调节作用。方法选取我院2017年4月至2019年5月收治的108例新诊断T2DM患者为研究对象,患者随机分为观察组和对照组各54例。两组患者均予以健康教育、饮食控制和运动锻炼等基础治疗。对照组患者在基础治疗的同时给予甘精胰岛素与阿卡波糖控制血糖;观察组患者在对照组基础上加用双歧杆菌四联活菌片治疗,1.5 g/次,3次/d,温开水服用。两组患者均连用12周。观察两组患者治疗前和治疗12周后血糖控制情况、β细胞功能、血清炎症指标[超敏C-反应蛋白(hs-CRP)、白介素(IL)-6和肿瘤坏死因子(TNF)-α]水平及氧化应激指标[谷胱甘肽过氧化物酶(GSH-PX)和晚期氧化蛋白产物(AOPP)]水平的变化。结果治疗12周后,两组患者血清FBG[(6.52±0.74)mmol/L、(5.78±0.62)mmol/L]和HbA1C水平[(7.42±0.93)%、(6.74±0.87)%]较治疗前明显下降,HOMA-β水平(44.78±4.79、51.87±5.27)较治疗前明显上升(均P<0.05),且观察组患者各指标水平变化幅度大于对照组(均P<0.05)。治疗后两组患者血清hs-CRP[(3.21±0.52)mg/L、(2.68±0.47)mg/L]、IL-6[(67.63±11.56)pg/mL、(50.69±9.42)pg/mL]和TNF-α水平[(26.82±4.12)ng/mL、(18.53±3.04)ng/mL]较治疗前明显下降(均P<0.05),且观察组患者各指标水平下降幅度大于对照组(均P<0.05);同时两组患者血清GSH-PX水平[(204.56±38.13)μg/mL、(248.62±40.42)μg/mL]较治疗前显著上升,AOPP水平[(51.27±10.52)μmol/L、(38.38±8.16)μmol/L]均较治疗前显著下降(均P<0.05),且观察组患者各指标水平变化幅度大于对照组(均P<0.05)。结论双歧杆菌四联活菌片辅助治疗新诊断T2DM患者可改善其糖代谢指标水平和胰岛素抵抗,有利于血糖达标,其作用机制可能与其能控制炎症反应和减轻氧化应激反应相关。Objective To explore the regulatory effect of Tetragenous viable Bifidobacterium Tablets(TVBT) adjuvant therapy on serum inflammatory factors and oxidative stress in newly diagnosed type 2 diabetic(T2 DM) patients. Methods A total of 108 patients with newly diagnosed T2 DM who were treated in our hospital from April 2017 to May 2019 were randomly divided into Observation group(n=54) and Control group(n=54). The patients in two groups were given basic treatments such as health education, diet control and exercise, as well as Insulin Glargine and Acarbose to control blood glucose;the patients in control group was given insulin Glargine and Acarbose to control blood sugar, the patients in observation group was additionally given TVBT 1.5 g tid orally, for 12 weeks. The changes of blood glucose, β-cell function, serum inflammation indexes [hypersensitive C-reactive protein(hs-CRP), interleukin(IL)-6, and tumor necrosis factor(TNF)-α] and oxidative stress indicators [glutathione peroxidase(GSH-PX) and advanced oxidation protein product(AOPP)] were observed before and after treatment. Results After 12 weeks′ treatment, the levels of serum FFBG[(6.52±0.74) mmol/L,(5.78±0.62) mmol/L] and HbA1 C [(7.42±0.93)%,(6.74±0.87)%] significantly decreased than before in two groups, while the HOMA-β levels(44.78±4.79, 51.87±5.27) were significantly higher than before(37.15±4.49, 36.97±4.58), with the ranges of changes in observation group was more significant than that in control group(all P<0.05). The levels of serum hs-CRP, IL-6 and TNF-α in two groups were significantly lower than before(all P<0.05), with the decrease in observation group was more significant than that in control group(all P<0.05). Moreover, the level of serum GSH-PX in two groups [(204.56±38.13) μg/mL,(248.62±40.42) μg/mL] significantly increased, while the AOPP level [(51.27±10.52) μmol/L、(38.38±8.16) μmol/L] decreased significantly than before(all P<0.05), with the changes in observation group was more significant than that in control

关 键 词：2型糖尿病 双歧杆菌四联活菌片 糖代谢 Β细胞功能 炎症因子 氧化应激 

分 类 号：R451[医药卫生—治疗学]