中药调周法治疗肾虚型育龄期多囊卵巢综合征临床研究  

Clinical Study on Method of Chinese Medicine Regulating Menstruation for Polycystic Ovary Syndrome of Kidney Deficiency Type at Child-Bearing Period

作　　者：高涛[1] 方晓红[1] 何嘉琳[1] 马景[1] 褚蕴 GAO Tao;FANG Xiaohong;HE Jialin;MA Jing;CHU Yun

机构地区：[1]杭州市中医院,浙江杭州310007

出　　处：《新中医》2020年第12期97-101,共5页New Chinese Medicine

摘　　要：目的:观察中药调周法治疗肾虚型育龄期多囊卵巢综合征(PCOS)的临床疗效。方法:选取94例肾虚型育龄期PCOS患者,按照随机数字表法分为对照组和观察组各47例。对照组给予口服枸橼酸氯米芬片、肌肉注射人绒毛膜促性腺激素治疗,观察组在对照组基础上给予中药调周法治疗,2组均治疗3个月经周期。比较2组临床疗效与治疗前后的中医证候积分、卵巢体积、子宫内膜厚度和性激素水平。结果:观察组总有效率85.11%,高于对照组的65.96%(χ2=4.663,P=0.027<0.05)。治疗后,2组月经失调、神疲乏力、腰膝酸软、耳鸣或耳聋、性欲减退积分均较治疗前降低(P<0.05),且观察组上述5项中医证候积分均低于对照组(P<0.05)。治疗后,对照组子宫内膜厚度及卵巢体积与治疗前比较,差异均无统计学意义(P>0.05);观察组子宫内膜厚度较治疗前增加(P<0.05),卵巢体积较治疗前缩小(P<0.05),且观察组子宫内膜厚度大于对照组(P<0.05),卵巢体积小于对照组(P<0.05)。治疗后,2组黄体生成素(LH)、卵泡刺激素(FSH)、LH/FSH水平及对照组睾酮(T)水平与同组治疗前比较,差异均无统计学意义(P>0.05);观察组T水平较治疗前降低(P<0.05),且低于对照组(P<0.05)。结论:中药调周法治疗肾虚型育龄期PCOS效果显著,可有效改善患者的临床症状,增加子宫内膜厚度,缩小卵巢体积,降低血清T水平。Objective:To observe the clinical effect of the method of Chinese medicine regulating menstruation for patients with polycystic ovary syndrome(PCOS)of kidney deficiency type at child-bearing period.Methods:A total of 94 patients with PCOS of kidney deficiency type at child-bearing period were selected and divided into the control group and the observation group according to the random number table,47 cases in each group.The control group was treated with oral clomiphene citrate and intramuscular injection of human chorionic gonadotropin.The observation group was additionally treated with the method of Chinese medicine regulating menstruation based on the treatment of the control group.Both groups were treated for three menstrual cycles.The therapeutic effect,Chinese medicine syndrome score,ovarian volume,endometrial thickness and level of sex hormone before and after treatment were compared between the two groups.Results:The total effective rate was 85.11%in the observation group,higher than that of 65.96%in the control group(χ2=4.663,P=0.027<0.05).After treatment,the scores of menstrual disorders,mental fatigue and weakness,soreness and weakness of waist and knees,tinnitus or deafness,and loss of libido in the two groups were all decreased when compared with those before treatment(P<0.05),and the above five scores of Chinese syndrome in the observation group were lower than those in the control group(P<0.05).There was no significant differences in the comparison of endometrial thickness and ovarian volume in the control group before and after treatment(P>0.05).The endometrial thickness in the observation group was increased when compared with that before treatment(P<0.05),and the ovarian volume was decreased(P<0.05);the endometrial thickness in the observation group was larger than that in the control group(P<0.05),and the ovarian volume was smaller than that in the control group(P<0.05).There was no significant differences in the comparison of the levels of luteinizing hormone(LH),follicle stimulating hormone(

关 键 词：多囊卵巢综合征 育龄期 肾虚 中药调周法 子宫内膜 卵巢体积 性激素 

分 类 号：R711.75[医药卫生—妇产科学]