疫情防控专题:新型冠状病毒肺炎患者中新型冠状病毒相关性结膜炎的筛查  

A special on epidemic prevention and control:screening for novel coronavirus related conjunctivitis among the patients with coronavirus disease 2019

作　　者：蓝倩倩[1] 曾思明[1] 廖欣[1] 徐帆[1] 齐虹[2] 李敏[1] Lan Qianqian;Zeng Siming;Liao Xin;Xu Fan;Qi Hong;Li Min(Department of Ophthalmology,The People's Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China;Department of Ophthalmology,Peking University Third Hospital Beijing 100191,China)

机构地区：[1]广西壮族自治区人民医院眼科,南宁530021 [2]北京大学第三医院眼科,100191

出　　处：《中华眼科杂志》2020年第6期433-437,共5页Chinese Journal of Ophthalmology

基　　金：广西壮族自治区卫健委自筹经费科研课题(Z2016623)。

摘　　要：本文于2020年4月16日优先发布于中华眼科杂志官网。目的探讨新型冠状病毒肺炎(COVID-19)患者新型冠状病毒相关性结膜炎的患病情况。方法前瞻性系列病例研究。纳入2020年2月16日至3月6日在广西壮族自治区人民医院邕武分院收治的确诊COVID-19患者81例,其中男性33例,女性48例,年龄(41.69±18.6)岁(3个月至85岁)。所有患者经眼科会诊筛查是否合并新型冠状病毒相关性结膜炎,筛查方法为先通过眼部症状问诊和结膜炎体征检查确定是否有结膜炎的临床表现,对有结膜炎临床表现的患者行结膜拭子新型冠状病毒核酸检测。结果81例患者中3例患者(3.70%)有眼部不适主诉,在确诊COVID-19之后第(16.67±9.29)d出现。3例患者的眼部体征均不符合病毒性结膜炎的典型表现,双眼结膜拭子新型冠状病毒核酸检测均为阴性,无证据支持新型冠状病毒相关性结膜炎的诊断。其余78例患者无结膜炎的症状和体征。结论COVID-19患者中未见新型冠状病毒相关性结膜炎,其患病率较低。This article was published ahead of print on the official website of Chinese Journal of Ophthalmology on April 16,2020.Objective To screen for novel coronavirus related conjunctivitis among patients with coronavirus disease 2019.Methods Prospective series case study.Eighty-one patients diagnosed as coronavirus disease 2019 in Guangxi Zhuang Autonomous Region People's Hospital were enrolled with ophthalmological consultation and screening for novel coronavirus related conjunctivitis,including the inquiring of eye symptoms and checking for conjunctivitis-related signs.Novel coronavirus nucleic acid testing of conjunctival swabs was performed on patients with clinical manifestations of conjunctivitis.Results Only 3 of the 81 patients(3.70%)complained of eye discomfort,which appeared on day 16.67±9.29 after the diagnosis of coronavirus disease 2019.The eye signs were not typical of viral conjunctivitis.Novel coronavirus nucleic acid tests of conjunctival swabs were negative in both eyes.There was no evidence to support the diagnosis of novel coronavirus related conjunctivitis.The remaining 78 patients showed no clinical symptoms or signs of conjunctivitis.Conclusions The occurrence of novel coronavirus related conjunctivitis may be low in patients with coronavirus disease 2019.

关 键 词：新型冠状病毒肺炎 2019新型冠状病毒 结膜炎 核酸类 

分 类 号：R563.1[医药卫生—呼吸系统] R777.31[医药卫生—内科学]