降钙素原指导脓毒症患者抗生素治疗的临床效果观察  

Clinical Effect of Procalcitonin-guided Antibiotic Therapy in Sepsis Patients

作　　者：李峰[1] Li Feng(Anyang District Hospital,Puyang,Henan Province,Puyang 455000)

机构地区：[1]河南省濮阳市安阳地区医院,濮阳455000

出　　处：《数理医药学杂志》2020年第8期1165-1167,共3页Journal of Mathematical Medicine

摘　　要：目的:观察降钙素原指导脓毒症患者抗生素治疗的临床效果。方法:选取2017年6月~2018年12月在某院重症医学科住院的180例脓毒症患者作为本次的研究对象,采用随机分配的方式进行分组,对照组给予经验性抗生素治疗方案,观察组在监测降钙素原的基础上指导抗生素使用治疗方案,对比分析两组患者的治疗效果,评测项目包括各项临床指标(住院治疗时间、抗生素使用时间、死亡率、治愈率)、治疗后辅助检查结果比较(APACHEⅡ评分、降钙素原、C反应蛋白、白细胞数)和试验组不同患者降钙素原水平比较(1d、3d、5d、7d)。结果:通过对比治疗,可以观察到两组患者的病情均有所好转,但观察组的住院治疗时间和抗生素使用时间均少于对照组,辅助检查结果观察组均优于对照组,观察组死亡患者的降钙素原水平明显高于治愈患者,差异有统计学意义(P<0.05)。结论:脓毒症患者的降钙素原水平监测,其结果能够指导临床合理应用抗生素,能够有效提高患者治愈率,改善预后,值得在临床广泛推广使用。Objective:To observe the clinical effect of procalcitonin-guided antibiotic therapy in sepsis patients.Methods:180 sepsis patients treated in a hospital from June 2017 to December 2018 were selected as the subjects of this study.They were randomly divided into two groups.The control group was given empirical antibiotic treatment program.The observation group was guided by antibiotic treatment program on the basis of monitoring procalcitonin.The therapeutic effects of the two groups were compared and analyzed.The evaluation items included various clinical indicators(hospitalization time,antibiotic use time,mortality,cure rate),post-treatment auxiliary examination results(APACHE II score,procalcitonin,C-reactive protein,white blood cell count)and procalcitonin levels of different patients in the experimental group(1d,3d,5d,7d).Results:Through comparative treatment,both groups of patients improved,but the observation group was less in hospitalization time and antibiotic use time than the control group,the auxiliary examination results showed that the observation group was better than the control group,and the procalcitonin level of the dead patients in the observation group was significantly higher than that of the patients,and the difference was statistically significant(P<0.05).Conclusion:The results of procalcitonin monitoring in sepsis patients can guide the rational use of antibiotics in clinic,and effectively improve the cure rate and prognosis of patients,which is worthy of extensive clinical promotion and application.

关 键 词：降钙素原 脓毒症 抗生素 临床效果 

分 类 号：R459.7[医药卫生—急诊医学]