联合检测Survivin与Egr-1在食管鳞癌中的表达及临床意义  

Expression and Clinical Significance of Combined Detection of Survivin and Egr-1 in Esophageal Squamous Cell Carcinoma

作　　者：董晓刚[1] 皮芹 安外尔·约麦尔阿卜拉 郭文佳[2] DONG Xiao-gang;PI Qin;Anwaier Yuemaier Abola;GUO Wen-jia(Department of Hepatobiliary and Pancreatic Surgery,Cancer Hospital Affiliated to Xinjiang Medical University,Urumqi,Xinjiang,830011 China;Cancer Prevention Institute,Cancer Hospital Affiliated to Xinjiang Medical University,Urumqi,Xinjiang,830011 China)

机构地区：[1]新疆医科大学附属肿瘤医院肝胆胰外科,新疆乌鲁木齐830011 [2]新疆医科大学附属肿瘤医院肿瘤防治研究所,新疆乌鲁木齐830011

出　　处：《中外医疗》2020年第15期4-8,共5页China & Foreign Medical Treatment

基　　金：新疆维吾尔自治区自然科学基金项目:食管鳞癌中辐射诱导因子Egr-1对IKKβ调控机制的研究(2016D01C370)。

摘　　要：目的探讨Survivin和Egr-1在食管鳞癌组织和正常食管组织中的表达情况,分析Survivin和Egr-1与食管鳞癌临床病理特征和预后的相关性。方法采用免疫组织化学染色方法检测2012年1月—2014年6月方便收集的80例食管鳞癌组织和20例正常食管组织中Survivin和Egr-1的蛋白表达水平,统计分析Survivin和Egr-1与临床病理特征和生存预后之间的关系。结果Survivin在食管鳞癌组织中阳性表达率为68.8%(55/80),高于在正常组织中的阳性表达率5.0%(1/20)(χ^2=26.39,P<0.05)。Egr-1在食管鳞癌中的低表达率为66.3%(53/80),高于正常组织中的15.0%(3/20)(χ^2=17.06,P<0.05)。Survivin蛋白在食管鳞癌中阳性高表达与患者的性别、年龄以及肿瘤的分化程度,差异无统计学意义(P>0.05),与食管鳞癌患者TNM分期、肿瘤的浸润深度、肿瘤大小以及淋巴结是否转移,差异有统计学意义(P<0.05)。Egr-1蛋白在食管鳞癌中阳性低表达与患者性别、肿瘤大小以及肿瘤浸润深度,差异无统计学意义(P>0.05),与食管鳞癌患者年龄、TNM分期、肿瘤分化程度以及淋巴结是否转移,差异有统计学意义(P<0.05)。随访结果显示食管鳞癌患者5年生存率为48.9%,中位生存时间为53.1个月。结论Survivin和Egr-1在食管鳞癌的发生发展中起重要作用,联合检测两者对判断食管鳞癌的预后有一定的指导意义,Survivin和Egr-1有望作为食管鳞癌的治疗或者预后预测靶标。Objective To investigate the expression of Survivin and Egr-1 in esophageal squamous cell carcinoma tissues and normal esophageal tissues,and to analyze the correlation between Survivin and Egr-1 and the clinicopathological characteristics and prognosis of esophageal squamous cell carcinoma.Methods The expression levels of Survivin and Egr-1 in 80 esophageal squamous cell carcinoma tissues and 20 normal esophageal tissues conveniently collected from January 2012 to June 2014 were detected by immunohistochemical staining.Survivin and Egr-1 were statistically analyzed.Relationship with clinicopathological characteristics and survival prognosis.Results The positive expression rate of Survivin in esophageal squamous cell carcinoma was 68.8%(55/80),which was higher than that in normal tissues 5.0%/(1/20)(χ^2=26.39,P<0.05).The low expression rate of Egr-1 in esophageal squamous cell carcinoma was 66.3%(53/80),which was higher than 15.0%(3/20)in normal tissues(χ^2=17.06,P<0.05).The positive expression of Survivin protein in esophageal squamous cell carcinoma was not significantly different from the patient's gender,age,and tumor differentiation(P>0.05).It was different from TNM staging,tumor invasion depth,tumor size,and lymph nodes in patients with esophageal squamous cell carcinoma.The difference was statistically significant(P<0.05).There was no statistically significant difference between the positive expression of Egr-1 protein in esophageal squamous cell carcinoma and the patient's gender,tumor size,and depth of tumor invasion(P>0.05).It was different from the age,TNM stage,tumor differentiation,and lymph nodes of patients with esophageal squamous cell carcinoma.The difference was statistically significant(P<0.05).The follow-up results showed that the 5-year survival rate of patients with esophageal squamous cell carcinoma was 48.9%,and the median survival time was 53.1 months.Conclusion Survivin and Egr-1 play an important role in the occurrence and development of esophageal squamous cell carcinoma.The combined

关 键 词：SURVIVIN EGR-1 食管鳞癌 免疫组化 

分 类 号：R5[医药卫生—内科学]