瘦素抵抗相关机制的研究进展  

Research progress of leptin resistance mechanism

作　　者：穆倩 张志国[1] 张翼飞[1] Mu Qian;Zhang Zhiguo;Zhang Yifei(Shanghai Clinical Center for Endocrine and Metabolic Diseases,Shanghai Institute of Endocrine and Metabolic Diseases,Department of Endocrine and Metabolic Diseases,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院内分泌代谢病科,上海市内分泌代谢病临床医学中心,上海市内分泌代谢病研究所,200025

出　　处：《中华内分泌代谢杂志》2020年第6期515-519,共5页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金面上项目(81670797);国家重点研发计划(2016YFC0901200)。

摘　　要：随着社会的发展和生活水平的提高,肥胖的发生率正不断增加。肥胖者高胰岛素血症出现的同时血清瘦素水平显著增高,而机体对瘦素的反应减弱,引发了人们对于"瘦素抵抗"的关注。在前期的研究中,人们将注意力集中于血清瘦素水平与瘦素受体的表达。在近几年的研究中,人们从不同的角度阐述了瘦素抵抗的发生机制。因此,本文就目前瘦素抵抗发生机制的进展作一综述,并对瘦素抵抗与胰岛素抵抗的关系及瘦素抵抗最新治疗措施作简要阐述。随着瘦素抵抗研究的不断深入,相信增加瘦素敏感性将成为肥胖治疗的一项重要措施。With the progress of society and the improvement of living standard,the incidence of obesity is increasing.Serum leptin level increased significantly in the obese patients with hyperinsulinemia.However,the response to leptin is weakened,and then"leptin resistance"is widely concerned.Previous studies have focused on serum leptin levels and leptin receptor expression.In recent years,the mechanism of leptin resistance has been elucidated from different perspectives.This article tries to review the recent progress in the mechanism for leptin resistance,and briefly discusses the relationship between leptin resistance and insulin resistance,as well as the latest treatment measures for leptin resistance.With the development of leptin resistance research,it is believed that the increasing leptin sensitivity will be an important measure in obesity treatment.

关 键 词：肥胖 瘦素抵抗 瘦素 瘦素受体 

分 类 号：R589.2[医药卫生—内分泌]