利培酮治疗颅脑损伤所致精神障碍的临床效果  

Clinical effect of Risperidone in the treatment of mental disorders induced by craniocerebral injury

作　　者：饶英华 秦明筠[1] 张训[1] RAO Ying-hua;QIN Ming-jun;ZHANG Xun(Department of Neurosurgery,Affiliated Brain Hospital of Guangzhou Medical University(Guangzhou Huiai Hospital),Guangdong Province,Guangzhou510370,China)

机构地区：[1]广州医科大学附属脑科医院(广州市惠爱医院)神经外科,广东广州510370

出　　处：《中国当代医药》2020年第19期64-66,70,共4页China Modern Medicine

基　　金：广东省广州市卫生健康科技项目(20191A010034)。

摘　　要：目的探讨利培酮对颅脑损伤所致精神障碍患者精神症状、神经功能及社会功能的影响。方法选取2017年10月~2019年10月我院收治的40例颅脑损伤所致精神障碍患者作为研究对象,按照随机数字表法分为观察组(20例)与对照组(20例)。观察组采用常规治疗联合利培酮治疗方法,对照组采用常规治疗方法。比较两组治疗前及治疗8周后的神经功能缺损评定量表(NIHSS)评分、阳性和阴性症状量表(PANSS)评分及日常生活能力量表(ADL)评分和不良反应量表(TESS)评分。结果治疗8周后,观察组患者的NIHSS总分和PANSS总分低于对照组,差异有统计学意义(P<0.05)。治疗8周后,观察组患者的ADL总分和TESS总分高于对照组,差异有统计学意义(P<0.05)。结论联合利培酮治疗可促进颅脑损伤所致精神障碍患者神经功能的恢复,改善患者精神症状和提高患者的社会功能。Objective To explore the influence of Risperidone on psychiatric symptoms,nerve function and social function in patients with mental disorders induced by craniocerebral injury.Methods A total of 40 patients with mental disorders induced by craniocerebral injury from October 2017 to October 2019 in our hospital were selected as the research objects.According to the random number table method,all participants were divided into the observation group(20 cases)and the control group(20 cases).The observation group was treated with routine therapy combined with Risperidone,while the control group was treated with routine therapy.The scores of National Institutes of Health Stroke scale(NIHSS),positive and negative syndrome scale(PANSS),activity of daily living(ADL)and treatment emergent symptom scale(TESS)were compared between the two groups before treatment and after 8 weeks of treatment.Results After 8 weeks of treatment,the total scores of NIHSS and PANSS in the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).After 8 weeks of treatment,the total scores of ADL and TESS in the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).Conclusion The combination of Risperidone can promote the recovery of neurological function,improve the mental symptoms and improve the social function of patients with mental disorders induced by craniocerebral injury.

关 键 词：颅脑损伤 精神障碍 利培酮 神经功能 社会功能 

分 类 号：R651.15[医药卫生—外科学]