前列地尔治疗早期糖尿病肾病的临床效果  

Clinical effect of Alprostadil on the treatment of early diabetic nephropathy

作　　者：张奇芬 杨明敏[2] 熊燕[1] 周海星[1] 余英 ZHANG Qi-fen;YANG Ming-min;XIONG Yan;ZHOU Hai-xing;YU Ying(The First Department of Internal Medicine,Nanchang Hongdu Hospital of TCM,Jiangxi Province,Nanchang330006,China;Department of Anesthesiology,Nanchang First Hospital,Jiangxi Province,Nanchang330008,China)

机构地区：[1]南昌市洪都中医院内一科,江西南昌330006 [2]南昌市第一医院麻醉科,江西南昌330008

出　　处：《中国当代医药》2020年第19期88-90,94,共4页China Modern Medicine

基　　金：江西省卫生计生委中医药科研项目(2017A161)。

摘　　要：目的探讨前列地尔注射液对治疗早期糖尿病肾病微量白蛋白尿的临床效果。方法选取2016年6月~2019年6月我院收治的180例早期糖尿病肾病患者作为研究对象,按照随机数字表法将其分为治疗组(90例)与对照组(90例)。两组患者均给予常规治疗,对照组采用常规治疗的基础上口服黄葵胶囊;治疗组在对照组基础上采用静脉注射前列地尔注射液治疗,两组患者疗程均为4周。比较两组患者治疗后的治疗总有效率,比较两组患者治疗前后的血尿素氮(BUN)、血肌酐(SCr)、糖化血红蛋白(HbA1c)及24 h尿微量白蛋白(mAlb),比较两组患者治疗后的不良反应发生情况。结果治疗组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗组患者治疗后的mAlb、BUN、SCr、HbA1c均低于治疗前,差异有统计学意义(P<0.05);治疗组患者治疗后的mAlb、BUN、SCr、HbA1c均低于对照组,差异有统计学意义(P<0.05)。两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论前列地尔联合黄葵胶囊治疗早期糖尿病肾病效果显著,能有效降低患者的24 h mAlb水平,延缓肾功能损伤,适于临床应用。Objective To investigate the clinical effect of Alprostadil Injection on microalbuminuria in early diabetic nephropathy(DN).Methods A total of 180 patients with early DN admitted to our hospital from June 2016 to June 2019 were selected as subjects,and divided into the treatment group(90 cases)and the control group(90 cases)according to the random number table.Patients in both groups were given conventional treatment.The control group was given oral Huangkui Capsules on the basis of conventional treatment.The treatment group was treated with intravenous Alprostadil Injection on the basis of the control group.The therapeutic course was 4 weeks in the two groups of patients.The total treatment efficiency of the two groups of patients after treatment was compared.Blood urea nitrogen(BUN),serum creatinine(SCr),glycosylated hemoglobin(HbA1c)and 24 h microalbumin(mAlb)were compared before and after treatment between the two groups.The incidence of adverse reactions after treatment between the two groups was compared.Results The total effective rate of treatment group was higher than that in the control group,the difference was statistically significant(P<0.05).The mAlb,BUN,SCr and HbA1c after treatment in the treatment group were lower than those before treatment,while mAlb,BUN,SCr and HbA1c after treatment in treatment group were lower than those in the control group,the differences were statistically significant(P<0.05).There were no significant differences in adverse reactions of two groups(P>0.05).Conclusion Alprostadil combined with Huangkui Capsule for the treatment of patients with early DN can effectively improve clinical curative effect,decrease 24 h mAlb,delay renal function injury and be suitable for clinical application.

关 键 词：糖尿病肾病 前列地尔 黄葵胶囊 尿微量白蛋白 肌酐 尿素氮 

分 类 号：R587.2[医药卫生—内分泌]