Pharmacokinetics of Hu-Pi-Cheng-Qi decoction administered via enema to rats with acute pancreatitis  

作　　者：Qiu-Ting Wu Huan Chen Jin Xiang Wen-Fu Tang Mei-Hua Wan 

机构地区：[1]Department of Integrated Traditional Chinese and Western Medicine,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China [2]GCP Center of West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China

出　　处：《Chinese Medical Journal》2020年第12期1510-1512,共3页中华医学杂志（英文版）

基　　金：This work was supported by the grants fromthe Science and Technology Agency of Sichuan Province Foundation Project(No.2016HZ0063);the National Natural Science Foundation of China(No.81774160 and 81974552).

摘　　要：To the Editor:Acute pancreatitis(AP)is a common digestive systemdisease without specialized treatment until recently.Gastrointestinal function plays essential role in AP treatment and could be restored with Da-Cheng-Qi decoction(DCQD)as evidenced by our previous clinical study.[1]Based on the formula composing principles and our clinical experience,according to the traditional Chinese medicine theory that the lung and the large intestine are internal and externally related,Huzhang and Gualoupi were added into DCQD to form a new formula named Hu-Pi-Cheng-Qi decoction(HPCQD)which could increase the effects of purging Fu-Organ and ventilating lung.Enema with HPCQDis effective against AP in clinical practice;however,the pharmacokinetic parameters of HPCQD after enema administration in AP is unclear.According to formula tissue pharmacology,prescription compatibility is based on its pharmacokinetics.Furthermore,the active ingredients types absorbed into the body and the metabolic process could be significantly affected by different compatibility.[2]Therefore,our purpose was to elucidate the pharmacokinetic parameters when HPCQD is absorbed into blood circulation through the rectum,the effective components and the distribution of HPCQD via enema administration on AP rats.

关 键 词：DECOCTION PANCREATITIS lung 

分 类 号：R285.5[医药卫生—中药学]