脂毒性在糖尿病心肌病发病机制中的研究进展  

The research progress of lipotoxicity in the pathogenesis of diabetic cardiomyopathy

作　　者：刘红霞 戚本玲[1] 刘丽华[1] LIU Hongxia;QI Benling;LIU Lihua(Department of Geriatrics,Union Hospital,Tongji Medical University of Science and Technology,Wuhan,430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院老年病科,武汉430022

出　　处：《临床心血管病杂志》2020年第5期406-409,共4页Journal of Clinical Cardiology

基　　金：国家自然科学基金项目(No:81571373)。

摘　　要：糖尿病心肌病(diabetic cardiomyopathy,DCM)定义为糖尿病患者在排除冠状动脉疾病、高血压或心脏瓣膜病的情况下发生的心脏功能障碍的心肌疾病。其是一种慢性疾病,有复杂的病理生理过程,在早期不易被察觉,而往往只在病变进展到心力衰竭时才得以被发现。糖尿病患者发生心力衰竭病死率高,但发病机制仍不明确,目前已初步认识到心肌脂毒性在DCM中的作用。因此,本文主要对近些年关于脂毒性在DCM发病机制中的作用作一综述。Diabetic cardiomyopathy(DCM)is defined as myocardial dysfunction occurring in patients with diabetes in the absence of coronary artery disease,hypertension,and valvular heart disease.DCM is a chronic disease,and has a complex pathophysiological process.Unfortunately,DCM is hard to be detected in its early stage,and only can be detected when the disease progresses to heart failure.The patients with diabetes are at high risk of mortality from heart failure,but the pathogenesis is still unclear.At present,the role of cardiac lipotoxicity in DCM has been preliminarily recognized.Therefore,this review expounds the current research progress on the role of lipotoxicity in the pathogenesis of diabetic cardiomyopathy.

关 键 词：糖尿病 脂毒性 心肌病 

分 类 号：R587.2[医药卫生—内分泌]