十溴二苯醚生产工人血清、头发和指甲中多溴二苯醚暴露水平及其相关性分析  

Exposure levels and correlation of polybrominated diphenyl ethers in serum, hair, and nail of workers from a deca-brominated diphenyl ether manufacturing plant

作　　者：付中建 孙桂兰[1] 孙文 刘玲[1] 李伟红[1] 李秋菊[1] 王德军[2] FU Zhong-jian;SUN Gui-lan;SUN Wen;LIU Ling;LI Wei-hong;LI Qiu-ju;WANG De-jun(Shouguang Center for Disease Control and Prevention,Shouguang,Shandong 262700,China;Shandong Center for Disease Control and Prevention,Jinan,Shandong 250014,China)

机构地区：[1]寿光市疾病预防控制中心,山东寿光262700 [2]山东省疾病预防控制中心,山东济南250014

出　　处：《环境与职业医学》2020年第6期579-585,共7页Journal of Environmental and Occupational Medicine

基　　金：山东省医药卫生科技发展计划项目(2013W159)。

摘　　要：[背景]十溴二苯醚(Deca-BDE)是一种应用广泛的溴系阻燃剂,具有价格低廉且阻燃性能良好等优点,但长期应用带来的环境污染和潜在的人群健康风险备受关注。Deca-BDE生产工人作为职业暴露人群,其Deca-BDE暴露水平及健康风险预计远高于普通人群,亟须开展Deca-BDE生产工人的暴露水平监测。[目的]分析Deca-BDE生产厂工人血清、头发和指甲中多溴二苯醚(PBDEs)暴露水平,并进一步探讨血清、头发和指甲中十溴二苯醚(BDE-209)水平的相关性。[方法]以山东某Deca-BDE工厂作为研究现场,选择30名Deca-BDE生产工人作为研究对象,收集每人的血清、头发和指甲样,采用气相色谱-质谱法分别检测3种生物样本中8种PBDEs同系物(BDE-28、BDE-47、BDE-100、BDE-99、BDE-154、BDE-153、BDE-183和BDE-209)的质量分数(后称"含量")。采用中位数(M)和第25、75百分位数(P25,P75)及最小值(Min)、最大值(Max)对PBDEs含量进行统计描述,分别采用Pearson和Spearman相关分析探讨血清-头发和血清-指甲中BDE-209含量的相关性。[结果]血清、指甲和头发样品中均可检出所有8种PBDEs同系物。血清中BDE-209检出率达100%,其含量的M(P25,P75)为6.39×10^3(2.37×10^3,2.43×10^4)ng·g^-1(以脂重计),其余7种PBDEs同系物总含量的M(P25,P75)为229(131,493)ng·g^-1(以脂重计);头发中BDE-209含量的M(P25,P75)达1.95×10^5(4.01×10^4,4.72×10^5)ng·g^-1(以干重计),其余7种PBDEs总含量的M(P25,P75)为5.45×10^3(1.58×10^3,1.42×10^4)ng·g^-1(以干重计);工人指甲中BDE-209含量的M(P25,P75)达2.26×10^6(9.90×10^5,2.90×10^6)ng·g^-1(以干重计),其余7种PBDEs同系物总含量的P25和M均为未检出,P75为975 ng·g^-1(以干重计)。相关分析显示,工人血清与头发中BDE-209含量呈正相关(r=0.625,P<0.01),工人血清与指甲中BDE-209含量呈正相关(rs=0.751,P<0.01)。[结论]Deca-BDE工厂作业工人BDE-209内暴露水平较高,面临潜在的职业健康风险。头发和指�[Background]Deca-brominated diphenyl ether(Deca-BDE)is one of the widely used brominated flame retardants due to its low price and high flame resistance,but it is also considered to have potential environmental pollution and human health risks.Workers occupationally exposed to Deca-BDE tend to have a higher external exposure level and a higher health risk than the general population.Therefore,the monitoring of exposure level of BDE-209 in relevant manufacturing workers is much needed.[Objective]This study measures and further evaluates the correlations of the levels of polybrominated diphenyl ethers(PBDEs)in serum,hair,and nail samples of BDE-209 manufacturing workers.[Methods]Blood,hair,and nail samples were collected from 30 Deca-BDE manufacturing workers of a Deca-BDE manufacturing plant in Shouguang City of Shandong Province.The levels of eight PBDEs(BDE-28,BDE-47,BDE-100,BDE-99,BDE-154,BDE-153,BDE-183,and BDE-209)in the three biological matrices were detected by gas chromatography-mass spectrometry(GC-MS),respectively.Median(M)(P25,P75),min,and max were used to describe the distributions of PBDEs levels,and then Pearson and Spearman correlation analyses were conducted to explore serum-hair and serum-nail BDE-209 correlations.[Results]All the eight homologues of PBDEs were detected in the serum,nail,and hair samples.The positive rate of BDE-209 in serum reached 100%,and its M(P25,P75)level was 6.39×10^3(2.37×10^3,2.43×10^4)ng·g^-1(lipid weight),and the M(P25,P75)level of the other seven PBDEs was 229(131,493)ng·g^-1(lipid weight).The M(P25,P75)level of BDE-209 in hair was 1.95×10^5(4.01×10^4,4.72×10^5)ng·g^-1(dry weight),the M(P25,P75)level of the remaining seven PBDEs was 5.45×10^3(1.58×10^3,1.42×10^4)ng·g^-1(dry weight).The M(P25,P75)level of BDE-209 in nail reached 2.26×10^6(9.90×10^5,2.90×10^6)ng·g^-1(dry weight),and the M(P25,P75)level of the remaining seven PBDEs was below limit of detection(LOD)(<LOD,975)ng·g^-1(dry weight).The correlation analysis results showed the level of BDE-209

关 键 词：BDE-209 作业工人 血清 头发 指甲 暴露水平 

分 类 号：R134[医药卫生—劳动卫生]