不同程度缺血性心脏病患者血浆支链氨基酸水平的分析  

Clinical study on plasma BCAAs level in patients with different degrees of ischemic heart diseases

作　　者：关彦钧[1] 李柏林[1] 黄光锐[1] GUAN Yan-jun;LI Bo-lin;HUANG Guang-rui(Emergency Department,Kaiping Central Hospital,Jiangmen 529300,China)

机构地区：[1]广东省开平市中心医院急诊科,广东江门529300

出　　处：《广东医科大学学报》2020年第4期446-448,共3页Journal of Guangdong Medical University

摘　　要：目的分析血浆支链氨基酸(BCAAs)水平与缺血性心脏病类型和程度的关系。方法选取无症状冠心病和心绞痛患者各50例及心肌梗死患者60例,分别检测每组患者的血浆总BCAAs(包括亮氨酸、异亮氨酸和缬氨酸)水平,并比较不同Killip分级心肌梗死患者BCAAs的表达水平。结果心绞痛患者的总BCAAs和亮氨酸表达高于无症状冠心病患者(P<0.01)。心肌梗死患者的亮氨酸、异亮氨酸、缬氨酸和总BCAAs水平均高于无症状和心绞痛患者(P<0.01)。不稳定型心绞痛患者的总BCAAs和亮氨酸水平高于稳定型心绞痛患者(P<0.05或0.01);心肌梗死KillipⅢ、Ⅳ级患者的总BCAAs表达水平明显高于Ⅰ、Ⅱ级患者,且Ⅳ级患者的亮氨酸水平高于Ⅲ级患者(P<0.01)。结论血浆BCAAs的水平随着缺血程度的加重表达增高,且以亮氨酸表达增高最为明显,或可作为缺血性心脏病事件发生和预后的临床参考指标。Objective To analyze the relationship between the plasma branched chain amino acid leucine(BCAAs)level and the type and degree of ischemic heart diseases.Methods 50 cases of asymptomatic coronary heart disease,50 cases of angina and 60 cases of myocardial infarction were selected for this study.The total plasma BCAAs(including leucine,isoleucine,and valine)level of each group was measures respectively and the expression level of BCAAs in patients with myocardial infarction with different Killip grades was compared.Results The patients with angina had the total BCAAs and leucine expression higher than the patients with asymptomatic coronary heart disease(P<0.01).The patients with myocardial infarction had the leucine,isoleucine,valine,and total BCAAs level higher than the patients with asymptomatic coronary heart disease and those with angina(P<0.01).The patients with unstable angina had the total BCAAs and leucine level higher than the patients with stable angina(P<0.05 or 0.01).The patients with KillipⅢorⅣmyocardial infarction had the total BCAAs level significantly higher than those with KillipⅠorⅡmyocardial infarction,and the patients with KillipⅣmyocardial infarction had the leucine level higher than those with KillipⅢmyocardial infarction(P<0.01).Conclusion The plasma BCAAs level increases with the increased expression of the degree of ischemia,and the expression of leucine shows the most significant increase.Therefore,the expression of plasma BCAAs may a possible clinical index for the occurrence and prognosis of ischemic heart disease.

关 键 词：心绞痛 心肌梗死 亮氨酸 异亮氨酸 缬氨酸 

分 类 号：R541[医药卫生—心血管疾病]