钆塞酸二钠增强MRI对原发性胆汁性胆管炎患者肝功能评估的可行性分析  

Feasibility of gadolinate enhanced MRI in evaluating liver function of primary biliary cholangitis

作　　者：罗钧 陈惠枚[1] 皮风玲 成彦霖 王亚弟 赵双全[1] LUO jun;CHEH Hui-mei;PI Feng-ling;CHENG Yan-lin;WANG Ya-di;ZHAO Shuang-quan(Department of Radiology,Bao’an District People’s Hospital,Shenzhen 518101,China)

机构地区：[1]广东省深圳市宝安区人民医院放射科,广东深圳518101

出　　处：《广东医科大学学报》2020年第4期479-482,共4页Journal of Guangdong Medical University

摘　　要：目的分析钆塞酸二钠(Gd-EOB-DTPA)增强磁共振成像(MRI)评估原发性胆汁性胆管炎(PBC)患者肝功能的可行性。方法21例PBC患者(PBC组)和21例肝炎后肝硬化患者(对照组)进行Gd-EOB-DTPA增强MRI检查,比较两组肝脏相对增强度(RE)和胆总管对比噪声比(CNR)。结果相同Child-Pugh分级的PBC患者肝脏RE和胆总管CNR随GdEOB-DTPA注射后时间延长而增加(P<0.01),相同时间点肝脏RE和胆总管CNR随着Child-Pugh分级增加而降低(P<0.01)。不同Child-Pugh分级的PBC组和对照组患者在各时间点肝脏RE和胆总管CNR差异无统计学意义(P>0.05)。结论Gd-EOB-DTPA增强MRI可用于评估PBC患者肝功能。Objective To investigate the feasibility of Gd-EOB-DTPA enhanced MRI in evaluating the liver function of primary biliary cholangitis(PBC).Methods Twenty-one patients with PBC(PBC group)and 21 with posthepatitic cirrhosis(control group)underwent Gd-EOB-DTPA enhanced MRI.The relative enhancement(RE)of liver and contrast noise ratio(CNR)of common bile duct were compared between two groups.Results Hepatic RE and common bile duct CNR were increased with Gd-EOB-DTPA injection time in PBC patients with same Child-Pugh grading,but they decreased with incremental Child-Pugh grading at same timepoint(P<0.01).After injecting Gd-EOB-DTPA,there was no significant difference in hepatic RE and common bile duct CNR between PBC group with different Child-Pugh grading and control group(P>0.05).Conclusion Gd-EOB-DTPA enhanced MRI is feasible to evaluate the liver function of PBC patients.

关 键 词：钆塞酸二钠 MRI 原发性胆汁性胆管炎 肝硬化 

分 类 号：R657[医药卫生—外科学]