A fluorescent probe operating under weak acidic conditions for the visualization of HOCl in solid tumors in vivo  

作　　者：Peng Wei Lingyan Liu Wei Yuan Jiajia Yang Ruohan Li Tao Yi 

机构地区：[1]State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,Donghua University,Shanghai 201620,China [2]College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,Shanghai 201620,China [3]Department of Chemistry,Fudan University,Shanghai 200438,China

出　　处：《Science China Chemistry》2020年第8期1153-1158,共6页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(21877013,21671043);the Initial Research Funds for Young Teachers of Donghua University。

摘　　要：Levels of reactive oxygen species(ROS)in cancer cells or in the tumor microenvironment differ noticeably from those in normal cells and cellular microenvironments because ROS play important roles in all aspects of tumor physiology.However,due to the lack of adequate tools,it is difficult to study the relationship between ROS,especially certain types of ROS(e.g.,HOCl),and cancer.We report herein an HOCl-specific fluorescent probe,FDOCl-20,containing a thiocarbamide group as a receptor,for the visualization of HOCl in solid tumors in vivo.This probe displays high selectivity and sensitivity to HOCl,and is appropriate for use in acidic conditions,including the tumor microenvironment.Using FDOCl-20 as a tool,we can visualize HOCl in solid tumors in vivo.Importantly,the fluorescent intensity of FDOCl-20 is proportional to tumor volume.Thus,FDOCl-20 is a useful tool to investigate the relationship between HOCl and the physiological processes of tumors.

关 键 词：fluorescent probe hypochlorous acid IMAGING solid tumor 

分 类 号：O657.3[理学—分析化学] R730.4[理学—化学]