清肺利咽汤治疗小儿化脓性扁桃体炎肺胃热盛证疗效及对患儿炎症因子和T淋巴细胞亚群的影响  

Clinical effect of Qingfei Liyan decoction in the treatment of children’s suppurative tonsillitis with hyperactivity of lung-stomach heat syndrome and its influence on the immune function and T lymphocyte subsets of peripheral blood

作　　者：延亮 刘鉴 闫曙光 范玉霞[1,4] YAN Liang;LIU Jian;YAN Shuguang(Department of Pediatrics,Xi'an Gaoxin Hospital,Xi'an,Shaanxi 710000)

机构地区：[1]西安高新医院儿科,陕西西安710000 [2]陕西省西安市中医医院儿科,陕西西安710021 [3]陕西中医药大学基础医学院方剂学教研室,陕西咸阳712046 [4]赣南医学院第三附属医院内一科,江西赣南341000

出　　处：《河北中医》2020年第4期528-532,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：陕西省科学技术厅2017年度陕西省科学重点研发计划项目(编号:2017SF-3964)。

摘　　要：目的观察清肺利咽汤治疗小儿化脓性扁桃体炎肺胃热盛证的临床疗效及对患儿炎症因子和外周血T淋巴细胞亚群的影响。方法将120例化脓性扁桃体炎肺胃热盛证患儿按照随机数字表法分为2组。对照组60例予常规西药治疗,治疗组60例在对照组治疗基础上加清肺利咽汤。2组均治疗1周。比较2组疗效;比较2组治疗前后血清炎症因子白细胞介素4(IL-4)、IL-6水平变化,外周血T淋巴细胞亚群CD3+、CD4+、CD8+及CD4+/CD8+水平变化,临床症状改善情况,血白细胞计数(WBC)、中性粒细胞百分比及C反应蛋白(CRP)变化。结果治疗组总有效率96.7%(58/60),对照组总有效率81.7%(49/60),治疗组疗效优于对照组(P<0.05)。2组治疗后IL-4、IL-6水平均较本组治疗前降低(P<0.05),且治疗组降低更明显(P<0.05)。2组治疗后CD3+、CD4+及CD4+/CD8+水平均较本组治疗前升高(P<0.05),CD8+较本组治疗前降低(P<0.05),且治疗后治疗组CD3+、CD4+及CD4+/CD8+水平均高于对照组(P<0.05),CD8+低于对照组(P<0.05)。2组治疗后WBC、中性粒细胞百分比及CRP均较本组治疗前降低(P<0.05),且治疗组降低更明显(P<0.05)。治疗组咳嗽、发热及扁桃体红肿消失时间均较对照组缩短(P<0.05)。结论清肺利咽汤治疗小儿化脓性扁桃体炎肺胃热盛证,能有效降低炎症因子水平,改善外周血T淋巴细胞亚群水平,改善临床症状。Objective To observe the effect of Qingfei Liyan decoction in the treatment of children’s suppurative tonsillitis with hyperactivity of lung-stomach heat syndrome and its influence on the immune function and T lymphocyte subsets of peripheral blood. Methods 120 children with pyogenic tonsillitis were divided into two groups according to the random number table method. 60 cases in control group were treated by conventional western medicine. 60 cases in treatment group were treated by Qingfei Liyan decoction on the basis of the control group. Both groups were treated for one week. The therapeutic effects of the two groups were compared. The levels of CD3^+,CD4^+,CD8^+and CD4^+/CD8^+in peripheral blood T-lymphocyte subsets,the levels of serum inflammatory factors,IL-4,IL-6,the improvement of clinical symptoms,the changes of white blood cell count( WBC),the percentage of neutrophils and C-reactive protein( CRP) were compared before and after treatment. Results The total effective rate was 96. 7%( 58/60) in the treatment group and 81. 7%( 49/60) in the control group. The clinical curative effect of the treatment group was better than that of the control group( P < 0. 05). The levels of IL-4 and IL-6 in the two groups were higher than those in the group before treatment( P < 0. 05). The levels of IL-4 and IL-6 in the treatment group were lower than those in the control group( P < 0. 05). The levels of CD3^+,CD4^+and CD4^+/CD8^+in the two groups were higher than those in the group before treatment( P < 0. 05),and CD8^+were lower than those in the group before treatment( P < 0. 05). The levels of CD3^+,CD4^+and CD4^+/CD8^+in the treatment group were lower than those in the control group( P < 0. 05),and CD8^+was lower than those in the control group( P < 0. 05). After treatment,WBC,neutrophil percentage and CRP levels in the two groups were lower than those in the group before treatment( P < 0. 05),and the decrease in the treatment group was more significant( P < 0. 05). The duration of cough,fever and tonsil swelling i

关 键 词：扁桃体炎 辨证 中药疗法 

分 类 号：R766.181[医药卫生—耳鼻咽喉科] R289.6[医药卫生—临床医学]