平均中性粒细胞体积在重症急性胰腺炎合并菌血症中的应用  

Application of mean neutrophil volume in severe acute pancreatitis with bacteremia

作　　者：林瀚 宋颖 蔡祺 郭平[1] 陈骊婷[1] LIN Han;SONG Ying;CAI Qi;GUO Ping;CHEN Liting(Department of Clinical Laboratory,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Shanghai Center for Clinical Laboratory,Shanghai 200126,China)

机构地区：[1]上海交通大学医学院附属瑞金医院检验科,上海200025 [2]上海市临床检验中心,上海200126

出　　处：《检验医学》2020年第7期660-662,共3页Laboratory Medicine

摘　　要：目的探讨外周血平均中性粒细胞体积(MNV)在重症急性胰腺炎(SAP)合并菌血症中的应用价值。方法选取SAP患者48例。采集患者入院第1天的外周血标本,检测白细胞(WBC)计数、中性粒细胞绝对数(NEUT#)、MNV、C反应蛋白(CRP)、降钙素原(PCT)并进行血培养,根据血培养结果将患者分为感染组和非感染组。采用受试者工作特征(ROC)曲线评估各项指标诊断SAP合并菌血症的效能。结果感染组与非感染组CRP和MNV差异有统计学意义(P<0.05),2个组之间WBC、NEUT#、PCT差异均无统计学意义(P>0.05)。ROC曲线分析结果显示,MNV诊断SAP合并菌血症的曲线下面积(AUC)为0.775,敏感性为84.6%,特异性为66.7%,最佳临界值为160.5;CRP的AUC为0.708,敏感性为92.3%,特异性为48.1%,最佳临界值为162.5 mg/L。结论 MNV或可作为SAP合并菌血症的早期辅助诊断指标。Objective To investigate the role of mean neutrophil volume(MNV) in severe acute pancreatitis(SAP) with bacteremia. Methods A total of 48 patients with SAP were enolled. Peripheral blood samples were collected at admission. White blood cell(WBC) count,the absolute value of neutrophil(NEUT#),MNV,C-reactive protein(CRP) and procalcitonin(PCT) determinations and blood culturing were performed. According to blood culturing results,the patients were classified into 2 groups,SAP with bacteremia group and SAP without bacteremia group. The efficiency of each parameter was analyzed by receiver operating characteristic(ROC) curve. Results CRP and MNV in the 2 groups had statistical significance(P<0.05). There was no statistical significance in WBC count,NEUT# and PCT between the 2 groups(P>0.05). ROC curve analysis showed that the area under curve(AUC) of MNV was 0.775,the sensitivity was 84.6%,the specificity was 66.7%,and the optimal cut-off value was 160.5. The AUC of CRP was 0.708,the sensitivity was 92.3%,the specificity was 48.1%,and the optimal cut-off value was 162.5 mg/L. Conclusions MNV may be used in the auxiliary diagnosis of SAP with bacteremia.

关 键 词：平均中性粒细胞体积 重症急性胰腺炎 菌血症 C反应蛋白 

分 类 号：R446.1[医药卫生—诊断学]