血浆凝血酶激活的纤溶抑制物和血清同型半胱氨酸在急性脑梗死中的诊断价值  

Roles of plasma thrombin-activatable fibrinolysis inhibitors and serum homocysteine in the diagnosis of acute cerebral infarction

作　　者：王伯玉 刘玲玲[1] 张勤[1] 姚瀚鑫[1] WANG Boyu;LIU Lingling;ZHANG Qin;YAO Hanxin(Department of Clinical Laboratory,the First Hospital of Jilin University,Changchun 130021,Jilin,China)

机构地区：[1]吉林大学第一医院检验科,吉林长春130021

出　　处：《检验医学》2020年第7期673-675,共3页Laboratory Medicine

摘　　要：目的探讨血浆凝血酶激活的纤溶抑制物(TAFI)与血清同型半胱氨酸(Hcy)水平在急性脑梗死(ACI)中的诊断价值。方法检测100例ACI患者(ACI组)和100名体检健康者(正常对照组)的血浆TAFI水平和血清Hcy水平。采用受试者工作特征(ROC)曲线评估TAFI和Hcy诊断ACI的效能。采用Pearson相关分析评估TAFI与Hcy的相关性。结果与正常对照组比较,ACI组血浆TAFI水平降低(P<0.05),血清Hcy水平升高(P<0.05)。ACI组TAFI、Hcy的阳性率分别为59%、65%,均高于正常对照组(1%、5%)(P<0.05)。ROC曲线分析结果显示,TAFI、Hcy单项检测和联合检测诊断ACI的曲线下面积(AUC)分别为0.907、0.828、0.949,最佳临界值分别为22.22μg/mL、14.95μmol/L、0.507,敏感性分别为78.3%、65.2%、88.0%,特异性分别为95.0%、100.0%、97.0%。Pearson相关分析结果显示,ACI组TAFI与Hcy无相关性(r=-0.075,P>0.05)。结论 TAFI和Hcy在ACI的诊断中有一定的价值。Objective To investigate the roles of plasma thrombin-activatable fibrinolysis inhibitor(TAFI) and serum homocysteine(Hcy) levels in the diagnosis of acute cerebral infarction(ACI). Methods The levels of TAFI and Hcy in 100 patients with ACI(ACI group) and 100 healthy subjects(healthy control group) were determined. Receiver operating characteristic(ROC) curve was used to evaluate the roles of TAFI and Hcy in the diagnosis of ACI. Pearson correlation analysis was used to evaluate the correlation between TAFI and Hcy. Results Compared with healthy control group,the level of TAFI in ACI group was decreased(P<0.05),and the level of Hcy in ACI group was increased(P<0.05). The positive rates of TAFI and Hcy in ACI group were 59% and 65%,respectively,which were higher than those in healthy control group(1% and 5%)(P<0.05). ROC curve analysis showed that areas under curves(AUC) of TAFI,Hcy single and combined determinations were 0.907,0.828 and 0.949,respectively. The optimal cut-off values were 22.22 μg/mL,14.95 μmol/L and 0.507,respectively. The sensitivities were 78.3%,65.2% and 88.0%,and the specificities were 95.0%,100.0% and 97.0%,respectively. Pearson correlation analysis showed that there was no correlation between TAFI and Hcy in ACI group(r=-0.075,P>0.05). Conclusions TAFI and Hcy play roles in the diagnosis of ACI.

关 键 词：凝血酶激活的纤溶抑制物 同型半胱氨酸 急性脑梗死 

分 类 号：R446.1[医药卫生—诊断学]