口腔鳞状细胞癌发病机制及药物干预的研究进展  

Research progress on pathogenesis and drug intervention of oral squamous cell carcinoma

作　　者：李玮柏 曹娟 刘璐瑶 张雯雯 郑适泽 董春玲[2] 李波 LI Weibo;CAO Juan;LIU Luyao;ZHANG Wenwen;ZHENG Shize;DONG Chunling;LI Bo(Experimental Teaching Center,Hospital of Stomatology,Jilin University,Jilin Province,Changchun130021,China;Department of Respiratory Medicine,the Second Hospital,Jilin University,Jilin Province,Changchun130041,China)

机构地区：[1]吉林大学口腔医院实验教学中心,吉林长春130021 [2]吉林大学第二医院呼吸内科,吉林长春130041

出　　处：《中国医药导报》2020年第21期42-45,共4页China Medical Herald

基　　金：吉林省教育厅“十三五”科学技术研究规划项目(JJKH20170839KJ);吉林省科技厅国际科技合作项目(20170414053GH);吉林大学白求恩计划科研项目(2018B27)。

摘　　要：口腔鳞状细胞癌(OSCC)是一种好发于颌面部皮肤及口腔黏膜的上皮恶性肿瘤,其发生是多种致病因素导致基因突变的结果,但发病机制尚未完全阐明。p16、p53、c-erbB-2、Bmi-1基因的突变与OSCC的发生和发展密切相关。传统中草药提取物汉黄芩素、姜黄素、甘草查尔酮及免疫抑制药物雷帕霉素对OSCC具有一定的抑制作用。本文对OSCC的发病机制及药物干预进行概述,为OSCC的研究和临床治疗提供一定的理论基础。Oral squamous cell carcinoma(OSCC)is an epithelial malignant tumor,which mainly occurs in maxillofacial skin and oral mucosa.The formation of OSCC results from multiple gene mutations,but its pathogenesis has not been fully elucidated.The mutations of p16,p53,c-erbB-2 and Bmi-1 genes are closely related to the occurrence and development of OSCC.Traditional Chinese herbal medicine extracts,such as wogonin,curcumin,licorice chalcone,and the immunosuppressant drug rapamycin have certain inhibitory effect on OSCC.This article reviews the pathogenesis of OSCC and drug intervention,which provides a theoretical basis for the research and treatment of OSCC.

关 键 词：口腔鳞状细胞癌 发病机制 药物干预 

分 类 号：R739.8[医药卫生—肿瘤]