细胞焦亡与PCSK9在动脉粥样硬化中的研究进展  

Research progress of pyroptosis and PCSK9 in atherosclerosis

作　　者：张梁 李婧[1] ZHANG Liang;LI Jing(Department of Cardiovascular,Tianyou Hospital Affiliated to Wuhan University of Science and Technology,Hubei Province,Wuhan430064,China)

机构地区：[1]武汉科技大学附属天佑医院心血管内科,湖北武汉430064

出　　处：《中国医药导报》2020年第21期54-57,共4页China Medical Herald

基　　金：湖北省自然科学基金资助项目(2018CFC817)。

摘　　要：动脉粥样硬化(AS)是多种心脑血管疾病的病理基础,严重威胁人类健康安全。AS的发病机制目前尚不完全清楚。最新的研究发现,AS的发生发展与前白蛋白转化酶枯草溶菌素9(PCSK9)以及细胞焦亡具有密切关系。本文就AS中PCSK9、细胞焦亡及PCSK9抑制剂的临床应用进展等方面进行综述。Atherosclerosis(AS)is the pathological basis of a variety of cardiovascular and cerebrovascular diseases,while seriously threatens human health and safety.The pathogenesis of AS is not yet fully understood.The latest research found that the occurrence and development of AS is closely related to the proprotein convertase subtilisin kexin type 9(PCSK9)and pyrolysis.This article reviews PCSK9 and pyrolysis in atherosclerosis and the clinical application progress of PCSK9 inhibitors.

关 键 词：动脉粥样硬化 前白蛋白转化酶枯草溶菌素9 细胞焦亡 炎症小体 半胱氨酸天冬酶 

分 类 号：R543.5[医药卫生—心血管疾病]