外源生长激素对多囊卵巢综合征患者IVF-ET治疗结局的影响  

Effect of exogenous growth hormone on the outcomes of IVF-ET for polycystic ovary syndrome patients

作　　者：吴正中 李雪梅 成艳君 刘兰云 覃春容 WU Zhengzhong;LI Xuemei;CHENG Yanjun;LIU Lanyun;QIN Chunrong(Department of Reproduction Center,Shenzhen Maternal&Child Healthcare Hospital Affiliated to Southern Medical University,Guandong Province,Shenzhen518000,China;Department of Obstetrics,Maternal&Child Health Care Hospital of Longgang District in Shenzhen,Guandong Province,Shenzhen518000,China)

机构地区：[1]南方医科大学附属深圳妇幼保健院生殖医学中心,广东深圳518000 [2]广东省深圳市龙岗区妇幼保健院产科,广东深圳518000

出　　处：《中国医药导报》2020年第21期113-116,共4页China Medical Herald

基　　金：广东省自然科学基金项目(2018A030313658);广东省深圳市科技创新委员会知识创新计划基础研究项目(JCYJ20160427191435515);广东省深圳市医疗卫生“三名工程”项目(SZSM201512012)。

摘　　要：目的探讨外源生长激素(GH)预处理对多囊卵巢综合征(PCOS)患者体外受精-胚胎移植(IVF-ET)结局的影响。方法选择2016年7月—2018年8月南方医科大学附属深圳妇幼保健院生殖医学中心首次接受IVF-ET治疗的120例PCOS患者为研究对象。根据促排卵过程中有无使用外源GH,将其分为处理组(68例)和对照组(52例)。比较两组实验室指标和临床结局。结果处理组促性腺激素总使用量、使用天数低于对照组(均P<0.05);处理组取卵日子宫内膜厚度、正常受精率、优胚率、临床妊娠率和活产率高于对照组(均P<0.05)。两组中重度卵巢过度刺激综合征发生率、获卵数、卵裂率、移植日子宫内膜厚度、流产率比较,差异无统计学意义(P>0.05)。结论外源GH预处理有助于改善PCOS患者的IVF-ET治疗结局。Objective To investigate the effect of exogenous growth hormone(GH)pretreatment on the outcomes of in vitro fertilization-embryo transfer(IVF-ET)in patients with polycystic ovary syndrome(PCOS).Methods From July 2016 to August 2018,120 cases with PCOS who undergoing their first IVF-ET in the Department of Reproduction Center of Shenzhen Maternal&Child Healthcare Hospital Affiliated to Southern Medical University were selected as objects.The patients were divided into treatment group(68 patients)and control group(52 patients)according to whether exogenous GH was used during ovulation induction.The laboratory indicators and clinical outcomes between two groups were compared.Results The total dosage of gonadotropins and the days of gonadotropins stimulation in treatment group were lower than those in control group(all P<0.05),while endometrial thickness on the day of ovum pick-up,the normal fertilization rate,high-quality embryo formation rate,clinical pregnancy rate and live birth rate in treatment group were higher than those in control group(all P<0.05).There were no statistically significant differences between the two groups in the incidence of moderate to severe ovarian hyperstimulation syndrome,the number of retrieved oocytes,the cleavage rate,embryo transfer day intrauterine membrane thickness and abortion rate(P>0.05).Conclusion The pretreatment with exogenous GH helps to improve the outcome of IVF-ET in PCOS patients.

关 键 词：多囊卵巢综合征 生长激素 促排卵 体外受精 胚胎移植 

分 类 号：R711.75[医药卫生—妇产科学]