多巴胺受体基因DRD4与家庭亲密度或矛盾性对大学生亲社会倾向的交互作用  

The interactions of dopamine D4 receptor and family cohesion or conflict on university students’ prosocial tendency

作　　者：王云强[1] 顾伟伟 邱逸鹭 王志琳 郭本禹[1] 葛芹玉[3] Yunqiang Wang;Weiwei Gu;Yilu Qiu;Zhilin Wang;Benyu Guo;Qinyu Ge(School of Psychology,Institute of Moral Education,Nanjing Normal University,Nanjing 210097,China;School of Marxism,Nanjing Medical University,Nanjing 211166,China;School of Biological Science and Medical Engineering,Southeast University,Nanjing 210009,China)

机构地区：[1]南京师范大学道德教育研究所,心理学院,南京210097 [2]南京医科大学马克思主义学院,南京211166 [3]东南大学生物科学与医学工程学院,南京210009

出　　处：《科学通报》2020年第19期2032-2046,共15页Chinese Science Bulletin

基　　金：国家社会科学基金(14CSH017)资助。

摘　　要：多巴胺D4受体基因(DRD4)与人类社会行为之间存在密切关联.已有研究较多关注DRD4-7R而忽视亚洲人群出现频率最高的DRD4-4R.DRD4基因多态性与家庭亲密度或矛盾性对亲社会倾向是否具有交互作用、是否存在性别差异等问题尚未有定论.本研究以中国大学生为被试,探究DRD4基因多态性与家庭亲密度或矛盾性对大学生亲社会倾向的交互作用,并采用显著性区域法和再参数化回归模型分析该交互作用是否符合差别易感性模型.结果发现,(1)DRD4-2R(7R)基因型与矛盾性对男性大学生利他的亲社会倾向、非DRD4-4R基因型与亲密度对男性大学生匿名的亲社会倾向、非DRD4-4R基因型与矛盾性对男性大学生利他的亲社会倾向、DRD4-3R(5R/6R)基因型与亲密度对男性大学生匿名的亲社会倾向具有显著的交互作用.即对男性大学生而言,与非携带者相比,家庭亲密度或矛盾性更能显著预测DRD4-2R(7R)、非DRD4-4R以及DRD4-3R(5R/6R)基因型携带者的亲社会倾向.(2)显著性区域法(Ros)和再参数化回归模型分析均表明,上述4个交互作用均符合差别易感性模型.Dopamine D4 receptor(DRD4)has been proved to be closely related to human social behavior.In particular,many studies have found that it interacts with family environment on prosocial behavior.However,there are some critical imperfection in current researches:1)Most of the related researches focus on DRD47 repeat allele(DRD4-7 R),while in fact there are great racial differences in the variable number of tandem repeats(VNTR)polymorphism of DRD4.In Asian population,the highest frequency of allele is DRD44 repeat allele(DRD4-4 R).2)There are three models to explain the interaction between DRD4 polymorphism and environmental factors on social behavior:diathesis-stress model,differential susceptibility model and vantage sensitivity model.The latter two models are supported by more evidences,but show inconsistent conclusions.3)The main analysis method of the above interaction is hierarchical regression,which is simple and easy,however,with noticeable disadvantages.This method only focuses on the two ends of environment variables,and does not set quantitative standards for the size of interaction effects.To solve this problem,Roisman et al.proposed the region of significance(Ro S)method,and Widaman et al.proposed a re-parameterized regression model.4)Since gender is the influencing factor of the relationship between DRD4 and social behavior,in the interaction between DRD4 and family factors on social behavior,does gender effect still exist?If it does,is it a gender-contingent effect or a gender-specific effect?This study explored the interaction of DRD4 gene polymorphism and family cohesion or conflict on prosocial tendencies of university students,and analyzed whether the interaction fitted the differential susceptibility model or not,using Ro S method and the re-parameterized regression model.Because of the similar function of DRD4-2 R and DRD4-7 R,the individuals carrying at least one DRD4-2 R and the individuals carrying at least one DRD4-7 R were combines as DRD4-2 R(7 R).Thus,there were two family sensitive gene typ

关 键 词：多巴胺受体基因 亲密度 矛盾性 亲社会倾向 差别易感性模型 

分 类 号：G444[哲学宗教—心理学]