隔药灸治疗原发性痛经Meta分析  

Meta-Analysis of Effect of Herbs-partition Moxibusition on Primary Dysmenorrhea

作　　者：张玉 王昕[2] ZHANG Yu;WANG Xin(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《实用中医内科杂志》2020年第6期77-81,共5页Journal of Practical Traditional Chinese Internal Medicine

基　　金：辽宁省中医药临床学(专)科能力建设项目(2018-125)。

摘　　要：目的通过对文献进行Meta分析,研究探讨隔药灸对原发性痛经的临床疗效。方法运用计算机检索的方法,对CNKI、VIP、Pub Med、WANFANGDATA、CBM等数据库进行检索,检索年限从2006年1月-2019年4月,以隔药灸治疗原发性痛经的随机对照试验为研究对象,并对纳入文献进行逐层筛选、质量评价和资料提取,采用Rev Man5.3软件进行数据分析。结果共纳入9篇研究,共包括678例,Meta分析结果显示隔药灸对于原发性痛经的临床总有效率比西药对照组更优RR=1.22,95%CI(1.14,1.30),I2=39%,P<0.00001,差异有统计学意义;在减轻原发性痛经痛经症状积分方面隔药灸组优于西药对照组,结果是基于删除1篇统计学异质性文章后的分析,差异有统计学意义P=0.80,I2=0,WMD=-2.78,95%CI(-3.43,-2.12),P<0.00001;同时隔药灸能够明显降低原发性痛经的中医症状评分,结果是基于删除1篇统计学异质性文章后的分析,敏感性分析P=0.60,I2=0%,WMD=-0.42,95%CI(-0.73,-0.11),P=0.008<0.05,差异有统计学意义。结论隔药灸能够明显减轻原发性痛经的疼痛,改善各种不适症状,是一种效果良好的临床干预手段。但由于纳入研究质量、数量限制、治疗方案较难实施盲法,隔药灸药饼组成及艾绒原料来源不一等多种偏倚因素对本次研究结果的影响,仍然需要大样本、多中心、高质量的随机对照试验来验证。Objective To study the clinical effect of herbs-partition moxibusition on primary dysmenorrhea through Meta-analysis of literature.Methods By using the method of computer retrieval of CNKI,VIP,Pub Med,WANFANG DATA and CBM,the retrieval period was from January 2006 to April 2019,and randomized controlled trials about herbs-partition moxibusition for treatment of primary dysmenorrhea were as the research objects.The literature selection,quality evaluation and information extraction were analyzed by using Rev Man5.3 software.Results A total of 9 studies were included,including 678 patients.Meta-analysis results showed that the total clinical effective rate of herbs-partition moxibusition for primary dysmenorrhea was better than that of the control group[RR=1.22,95%CI(1.14,1.30),I2=39%,P<0.00001],and the difference was statistically significant.In terms of alleviating dysmenorrhea symptom scores in patients with primary dysmenorrhea,the herbs-partition moxibusition group was superior to the western medicine control group.The results were based on the analysis after removing 1 article of statistical heterogeneity,and the difference was statistically significant[P=0.80,I2=0,WMD=-2.78,95%CI(-3.43,-2.12),P<0.00001].At the same time,moxibustion can significantly reduce the TCM symptom score of primary dysmenorrhea.The results were based on the analysis after deleting 1 article of statistical heterogeneity.And the difference was statistically significant[P=0.60,I2=0%,WMD=-0.42,95%CI(-0.73,-0.11),P=0.008<0.05].Conclusion Herbs-partition moxibusition can obviously reduce the pain of patients with primary dysmenorrhea and relieve the symptoms of patients.However,due to the limitation of the quality and quantity of the included studies,and the difficulty in the implementation of the blind method,the influence of various biased factors such as the composition of separated moxibustion cake and the different sources of moxibustion raw materials on the results of this study,a large-sample,high-quality,multicenter randomized contro

关 键 词：隔药灸 原发性痛经 随机对照试验 META分析 

分 类 号：R271[医药卫生—中医妇科学]