自身免疫耐受失调及其在免疫性血小板减少症发病机制中的研究进展  

Advances in research on the autoimmune tolerance disorder and pathogenesis in immune thrombocytopenia

作　　者：陈哲 郭成山[1] Chen Zhe;Guo Chengshan(Department of Rheumatology and Immunology,the Affiliated Shenzhen Baoan Hospital of Southern Medical University,the Second Affiliated Hospital of Shenzhen University,Shenzhen 518101,China)

机构地区：[1]南方医科大学附属深圳宝安医院,深圳大学第二附属医院风湿免疫科,广东深圳518101

出　　处：《国际免疫学杂志》2020年第2期196-200,共5页International Journal of Immunology

基　　金：国家自然科学基金(81270577);深圳市科创委基础研究项(JCYJ20160427191026117)。

摘　　要：免疫调节细胞数量及功能异常是导致自身抗原耐受机制破坏的重要原因之一。免疫性血小板减少症(immune thrombocytopenia,ITP)为一种自身免疫性疾病,机体的自身免疫耐受机制失调导致免疫系统异常激活,不仅产生了数量异常的免疫因子,更产生了大量自身抗体,引起血小板过度破坏,现就近年ITP中免疫调节细胞功能失调机制的研究进行综述。The abnormal quantity and function of immunomodulatory cells is one of the important reasons for the disturbance of autoantigen tolerance.Immune thrombocytopenia(ITP)is a kind of autoimmune diseases.Due to the imbalance of autoimmune tolerance in ITP,the abnormal activating immune system produces a lot of abnormal immune factors as well as a large number of antiplatelet autoantibodies leading to excessive destruction of platelets.In this review,recent studies on the mechanism of immune regulatory cell dysfunction in ITP are described.

关 键 词：免疫性血小板减少症 自身免疫耐受 免疫调节细胞 

分 类 号：R5[医药卫生—内科学]