复合免疫佐剂在疫苗开发中的应用研究进展  

Research progress on the application of compound immunoadjuvants in vaccine development

作　　者：李慧[1] 宋杰[1] 董少忠[1] Li Hui;Song Jie;Dong Shaozhong(Institute of Medical Biology,Chinese Academy of Medicine Science and Peking Union Medical College,Yunnan Key Laboratory of Vaccine Research&Developmenton Severe Infections Disease,Kunming 650118,China)

机构地区：[1]中国医学科学院,北京协和医学院,医学生物学研究所,云南省重大传染病疫苗研发重点实验室,昆明650118

出　　处：《国际免疫学杂志》2020年第2期201-208,共8页International Journal of Immunology

基　　金：云南省重大科技专项计划-生物医药重大专项(2018ZF006)。

摘　　要：随着新型疫苗的不断发展,研发能与疫苗安全高效配伍增强免疫应答的新型佐剂已迫在眉睫。目前研究表明单一佐剂很容易引发一种特定单一类型的辅助T细胞(helper T cell,Th)1或Th2反应,难以引起理想的免疫反应。复合佐剂作为疫苗佐剂研发的新趋势和热点,将两种或两种以上的免疫佐剂进行联合应用,协调发挥各自的优势,实现最大的佐剂效应,展现了复合佐剂协同作用的有利优势,为进一步开发新型佐剂提供了新的思考方向。With the development of new vaccine research,prompting for the research of novel types of safer and more efficient vaccines and adjuvants,which can greatly enhance immune response,is becoming extremely urgent for us.Current studies have shown that the immunoprotective effects of a single adjuvant can easily trigger a specific single type of helper T cell(Th)1 or Th2 response,which is difficult to cause an ideal immune response.Therefore,the review aims to summarize the vaccine complex adjuvants,as a new trend and hotspot in the research,combine two or more kinds of immunoadjuvants and give full play to their respective advantages to achieve maximum adjuvant effect.The advantageous advantages of synergistic effects of complex adjuvants can be shown clearly.It provides new ideas and strategies for the development of novel adjuvants for human use.

关 键 词：复合佐剂 疫苗 研究 

分 类 号：R3[医药卫生—基础医学]