特尔立治疗幼儿急疹合并粒细胞减少症效果观察  

Clinical effect of rhG-CSF in treatment of exanthema subitum with angranulocytosis

作　　者：徐燕霞[1] 张鸿彦[1] 李晓跃[1] 刘韵[1] 李佳泽[1] 王嘉琳 Xu Yanxia;Zhang Hongyan;Li Xiaoyue;Liu Yun;Li Jiaze;Wang Jialin(Department of Pediatrics,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院群力院区儿内科,150001

出　　处：《国际免疫学杂志》2020年第3期282-285,共4页International Journal of Immunology

摘　　要：目的:探讨特尔立[人粒细胞巨噬细胞集落刺激因子(recombinant human granulocyte-macrophage colony stimulating factor,rhG-CSF)]治疗幼儿急疹合并粒细胞减少症患儿的临床疗效。方法:收集2019年1月至2019年7月于哈尔滨医科大学附属第一医院群力院区儿内科门/急诊确诊为幼儿急疹合并粒细胞减少症患儿126例,随机分为对照组和实验组,每组63例。对照组未使用任何药物,仅使用物理降温;实验组应用特尔立皮下注射。对两组患儿连续进行外周血象分析,检测其白细胞总数(white blood cells,WBC)和中性粒细胞绝对值(absolute neutrophil count,ANC)。结果:与对照组相比,实验组退热、出疹时间明显缩短(t值分别为43.51和47.25,P值均<0.05);但皮疹持续时间无明显差异(t=0.88,P>0.05)。血常规显示实验组WBC、ANC在应用rhG-CSF后第3 d和5 d时明显高于对照组(WBC:F值分别为17601.31和32040.11,P值均<0.05;ANC:F值分别为20526.57和31701.91,P值均<0.05)。结论:特尔立通过快速提高外周血中白细胞、中性粒细胞数值,达到缩短患儿病程的作用,且临床安全有效。Objective To investigate the clinical efficacy of recombinant human granulocyte-macrophage colony stimulating factor(rhG-CSF)in the treatment of exanthema subitum with granulocytopenia.Methods A total of 126 cases of children with infantile acute rash and granulocytopenia diagnosed in the Department of Pediatrics/Emergency of Qunli District,the First Affiliated Hospital of Harbin Medical University were collected from January 2019 to July 2019.All participants were randomly divided into control group and experimental group,with 63 cases in each group.No drugs were used in the control group,expect physical cooling;the experimental group was treated with subcutaneous injection of rhG-CSF.The total number of white blood cells(WBC)and the absolute neutrophil count(ANC)were measured.Results Compared with the control group,the antipyretic and eruption time of the experimental group was significantly shortened(t values were 43.51 and 47.25 respectively,both P values<0.05);but there was no significant difference in the duration of the rash(t=0.88,P>0.05).Blood routine examination showed that WBC and ANC in the experimental group was significantly higher than that in the control group at the 3rd day and 5th day(WBC:F values were 17601.31 and 32040.11 respectively,all P values<0.05;ANC:F values were 20526.57 and 31701.91respectively,all P values<0.05)after subcutaneous injection of rhG-CSF.Conclusion rhG-CSF can shorten the disease course of children by rapidly increasing the number of leukocytes and neutrophils in peripheral blood,which is safe and effective in clinic.

关 键 词：幼儿急疹 粒细胞减少症 人粒细胞巨噬细胞刺激因子 

分 类 号：R725.1[医药卫生—儿科]