镁基合金可生物降解支架血管内应用研究进展  

Advances in research on intravascular applications of biodegradable magnesium alloy stents

作　　者：孔令华 贺迎坤 李天晓 张一林 何艳艳 朱世杰[2] KONG Linghua;HE Yingkun;LI Tianxiao;ZHANG Yilin;HE Yanyan;ZHU Shijie(Department of Cerebrovascular Disease,People's Hospital of Zhengzhou University,Henan Provincial People's Hospital,Henan Provincial Neurointerventional Engineering Research Center,Zhengzhou,Henan Province 450003,China)

机构地区：[1]郑州大学人民医院(河南省人民医院)脑血管病科,河南省神经介入研发与应用工程研究中心,450003 [2]郑州大学材料科学与工程学院

出　　处：《介入放射学杂志》2020年第6期626-630,共5页Journal of Interventional Radiology

基　　金：国家自然科学基金(81601583)。

摘　　要：在近半个世纪发展过程中,血管内永久植入金属支架造成的慢性炎性反应、支架内再狭窄及血栓形成等不足日益显现。支架的生物可降解特性理论上解决了永久性裸金属支架植入后相关并发症,生物可吸收支架(BRS)成为近年研究热点。依据BRS主要成分,可分为生物可吸收聚合物血管支架(BPVS)和可生物降解金属合金支架(BMAS)。镁基BMAS(Mg-BMAS)具有良好的力学结构特性和生物相容性,广泛应用于人体血管。该文就Mg-BMAS在脑血管、周围血管、循环大动脉和冠状动脉的临床前研究和临床应用作一综述,进一步探讨其优缺点、相应优化措施及应用前景。With the development of stent therapy in the last half century,its complications caused by permanent implantation of metal stent,such as chronic inflammatory reaction,stent restenosis and thrombosis,are becoming more and more common.Theoretically,the biodegradability of the stentscan resolve the complications associated with permanent bare metal stent implantation,thus,bioresorbable stent(BRS)has become a research hot spot in recent years.Based on its strut materials,BRS can be divided into bioresorbable polymeric vascular scaffold(BPVS)and biodegradable metallic alloy scaffold(BMAS).Asit carriesexcellentmechanical structural characteristics and good biocompatibility,the biodegradable magnesium alloy stent(Mg-BMAS)has been widely used in human blood vessels.This paper aims to make a comprehensive review about the preclinical studies and clinical applications of Mg-BMAS in cerebrovascular vessels,peripheral vessels,cardiopulmonary larger arteries and coronary arteries,so as to further explain its advantages,disadvantages,corresponding optimization measures and application prospects.

关 键 词：生物可吸收支架 镁合金可降解支架 脑血管疾病 冠心病 严重肢体缺血 

分 类 号：R541.1[医药卫生—心血管疾病]