左西孟旦对急性心肌梗死并发心力衰竭患者LVEF及BNP水平的影响  

Effect of Simendan on LVEF and BNP Levels in Patients with Acute Myocardial Infarction Complicated with Heart Failure

作　　者：马成龙 MA Cheng-long(Department of Cardiology,Zhongyi Northeast International Hospital Co.,Ltd.,Shenyang 110000,China)

机构地区：[1]中一东北国际医院有限公司心内科,辽宁沈阳110000

出　　处：《中国医药指南》2020年第20期103-104,共2页Guide of China Medicine

摘　　要：目的探究急性心肌梗死并发心力衰竭患者采用左西孟旦对其LVEF与BNP水平的影响。方法于本院2018年3月至2020年3月这一期间,选取本院收治的70例急性心肌梗死并发心力衰竭患者,并按照数字表法分为2组,对比组实施常规治疗,实验组在常规治疗前提下加用左西孟旦治疗,并对两组患者的LVEF、BNP与不良反应情况进行比较。结果对比组与实验组患者治疗前LVEF水平的比较发现没有统计学意义(P>0.05);对比组与实验组患者治疗后LVEF水平均比治疗前高(P1<0.05;P2<0.05),并且实验组治疗后LVEF水平比对比组高(P<0.05);对比组与实验组患者治疗前BNP水平的比较发现没有统计学意义(P>0.05);对比组与实验组患者治疗后BNP水平均比治疗前高(P1<0.05;P2<0.05),并且实验组治疗后BNP水平比对比组高(P<0.05);对比组治疗过程中没有产生不良反应,实验组治疗过程中出现1例低血压与1例室性早搏,通过针对性治疗后痊愈。结论急性心肌梗死并发心力衰竭患者采用左西孟旦治疗,可提高LVEF水平,降低BNP水平。Objective To investigate the effect of simendan on LVEF and BNP levels in patients with acute myocardial infarction complicated with heart failure.Methods From March 2018 to March 2020,70 patients with acute myocardial infarction complicated with heart failure admitted to our hospital were selected and divided into two groups according to the digital table method.The control group received conventional treatment,while the experimental group received simendan under the premise of conventional treatment.LVEF,BNP and adverse reactions of the two groups were compared.Results There was no significant difference in LVEF level between the control group and the experimental group before treatment(P>0.05).LVEF levels of patients in the control group and the experimental group were higher than those before treatment(P1<0.05;P2<0.05),and LVEF level in the experimental group was higher than that in the control group after treatment(P<0.05).There was no significant difference in BNP levels between the control group and the experimental group before treatment(P>0.05).The BNP levels in the control group and the experimental group were higher than before treatment(P1<0.05;P2<0.05),and BNP level in the experimental group was higher than that in the control group after treatment(P<0.05).There were no adverse reactions in the treatment process of the contrast group,and 1 case of hypotension and 1 case of ventricular premature beat occurred in the treatment process of the experimental group,which were cured by targeted treatment.Conclusion Simendan can improve LVEF level and reduce BNP level in patients with acute myocardial infarction complicated with heart failure.

关 键 词：左西孟旦 急性心肌梗死 心力衰竭 LVEF BNP 影响 

分 类 号：R542.22[医药卫生—心血管疾病] R541.6[医药卫生—内科学]