Grape Seed Procyanidin Extract Attenuate Sodium Fluoride-induced Oxidative Damage and Apoptosis in Rat Kidneys  

作　　者：WANG Er Hui YU Zeng Li PING Guan Fang ZHAI De Sheng 

机构地区：[1]Department of Nutrition and Food Hygiene,College of Public Health,Xinxiang Medical University,Xinxiang 453003,Henan,China [2]Department of Pharmacy,The First Affiliated Hospital,Xinxiang Medical University,Weihui 453100,Henan,China

出　　处：《Biomedical and Environmental Sciences》2020年第6期454-457,共4页生物医学与环境科学（英文版）

基　　金：supported by the National Natural Science Foundation of China Grant No.81703230;the Key Scientific Research Project of Universities in Henan Province Grant No.17A330005。

摘　　要：Fluoride is widely distributed in nature,and it can lead to fluorosis if intake is excessive.In addition to its established effects on the skeleton and teeth,fluoride can also exert toxic effects on the kidneys.Fluoride can induce abnormal renal function in humans and other animals[1-3],but the mechanisms through which fluoride exerts such effects remain obscure.

关 键 词：FLUORIDE SKELETON INTAKE 

分 类 号：R599.1[医药卫生—内科学]