巨核-红系祖细胞分化与调控机制的新进展  

Advances in differentiation and regulation mechanisms of megakaryocytic-erythroid progenitors

作　　者：任翔 郑以州[1] Ren Xiang;Zheng Yizhou(State Key Laboratory of Experimental Hematology,National Clinical Research Center for Blood Diseases,Institute of Hematology&Blood Diseases Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300020,China)

机构地区：[1]中国医学科学院北京协和医学院血液病医院(中国医学科学院北京协和医学院血液学研究所)实验血液学国家重点实验室,国家血液系统疾病临床医学研究中心,天津300020

出　　处：《国际输血及血液学杂志》2020年第3期229-232,共4页International Journal of Blood Transfusion and Hematology

基　　金：国家自然科学基金(81770119)。

摘　　要：巨核-红系祖细胞(MEP)是骨髓中一群特殊的造血祖细胞,能够分化为巨核祖细胞与红系祖细胞,对血小板及红细胞的生成具有十分重要的意义。然而,对MEP的特征与鉴定方法存在一定的争议。近年,随着单细胞测序技术及更加准确的分选策略的应用,使得对MEP的鉴定及其造血特点的认识更加准确与明晰,尤其是对其分化与调控机制的研究,对于认识与探索一些疾病状态下的异常造血机制具有重要的参考价值。笔者拟就MEP发育及调控机制的研究现状进行介绍。Megakaryocytic-erythroid progenitors(MEP)are a special group of hematopoietic progenitors in the bone marrow that can differentiate into megakaryocyte progenitors and erythroid progenitors,which are of great significance for the generation of platelets and red blood cells.However,the characteristics and identification strategy of MEP are controversial.Recently,with the application of single-cell sequencing technology and more accurate sorting strategy,the identification and characteristics of MEP have been more precise and clear,especially the study of their differentiation and regulatory mechanisms,which would be significantly important for the understanding and exploring study of abnormal hematopoietic mechanisms in some diseases.This article intends to review the research advances in cell differentiation and fate decision of MEP.

关 键 词：巨核-红系祖细胞 细胞分化 转录因子 细胞周期 异常造血 血液病 

分 类 号：R329.25[医药卫生—人体解剖和组织胚胎学]