鼻饲枸橼酸莫沙必利对腹部手术后胃瘫患者预后的影响  

Effect of nasal feeding of mosapride citrate on prognosis of patients with gastroparesis after abdominal surgery

作　　者：钟蔼云 满伟华 李亚琳[1] 花海洋[2] ZHONG Ai-yun;MAN Wei-hua;LI Ya-lin;HUA Hai-yang(Department of General Surgery,the Second Affiliated Hospital of Hebei North University,Zhangjiakou,075100,China;Department of Gastroenterology,Chengde Central Hospital,Chengde 067000,China)

机构地区：[1]河北北方学院附属第二医院普外科,河北张家口075100 [2]承德市中心医院消化内科,河北承德067000

出　　处：《中国中西医结合消化杂志》2020年第7期489-493,共5页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：河北省医学科学研究课题(No:20191297)。

摘　　要：[目的]探究鼻饲枸橼酸莫沙必利对腹部术后胃瘫患者症状缓解和胃肠功能改善的作用。[方法]选取2018年4月~2019年4月收治的93例腹部术后胃瘫患者作为实验对象,数字随机法分成2个组。对照组(46例)常规禁食、维持酸碱、电解质和水平衡等保守治疗,观察组(47例)于常规治疗基础上经鼻饲管回输枸橼酸莫沙必利治疗,对比2组患者治疗总有效率、胃电图参数、胃动素、胃泌素的变化情况,记录2组患者治疗期间并发症发生情况。[结果]观察组治疗总有效率为85.11%,高于对照组(67.39%),差异有统计学意义(χ^2=4.040,P<0.05);相较于治疗前,治疗后2组患者胃电图参数主功率、主频率和正常节律占比均显著增加,胃动过缓显著减少,组间对比观察组4项参数变化均优于对照组(P<0.05);治疗结束时观察组胃动素、胃泌素等激素水平明显高于对照组(P<0.05);观察组胃肠功能障碍、并发症等发生率均低于对照组(P<0.05)。[结论]鼻饲枸橼酸莫沙必利治疗腹部术后胃瘫患者可促进胃肠激素分泌,提高了有效率且安全性较高。[Objective]To investigate the effect of nasalgastric feeding of mosapride citrate on clinical symptoms and gastrointestinal function in patients with postoperative gastroparesis.[Methods]A total of 93 patients with abdominal hemorrhoids who underwent abdominal surgery from April 2018 to April 2019 were enrolled in the study.The patients were divided into two groups by digital randomization method.The control group was routinely fasted and maintained acid-base/electrolyte and conservative treatment such as water balance,47 patients in the observation group were treated with mosapride citrate via nasogastric tube on the basis of conventional treatment.The total effective rate,electrogastrogram parameters,motilin(MTL),and the two groups were compared.Changes in gastrin(GAS)were recorded and complications were recorded during treatment in both groups.[Results]The total effective rate of the observation group was 85.11%,higher than that of the control group 67.39%,χ^2=4.040,P<0.05.Compared with the pre-treatment,the main power,main frequency and normal rhythm ratio of the two groups were significantly increased after treatment.The changes in the parameters of the observation group were better than those in the control group(P<0.05).The levels of GAS and MTL in the observation group were significantly higher than those in the control group(P<0.05).The incidence of dysfunction and complications were lower than those of the control group(P<0.05).[Conclusion]Nasalgastric feeding of mosapride citrate can promote the secretion of gastrointestinal hormones in patients with abdominal gastroparesis after surgery.It can improve the efficiency of treatment and safety.

关 键 词：腹部手术 胃瘫 枸橼酸莫沙必利 胃动素 胃泌素 

分 类 号：R656[医药卫生—外科学]