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作 者:郑巧伟[1] 任晓东[1] 罗赛赛 董亚琳[1] 魏友霞[1] ZHENG Qiao-wei;REN Xiao-dong;LUO Sai-sai;DONG Ya-lin;WEI You-xia(Department of Pharmacology,The First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061)
机构地区:[1]西安交通大学第一附属医院药学部,西安710061
出 处:《中南药学》2020年第7期1252-1256,共5页Central South Pharmacy
基 金:陕西省自然科学基金面上项目(编号:2018JM7053);西安交通大学第一附属医院院基金(编号:2016MS-06)。
摘 要:目的探讨耐碳青霉烯铜绿假单胞菌血流感染(CRPA-BSI)的临床特征、危险因素及治疗结局。方法回顾性分析某三甲教学医院2010-2019年铜绿假单胞菌血流感染(PA-BSI)患者的临床资料,采用单因素及Logistic回归分析CRPA-BSI的危险因素。结果纳入224例PA-BSI患者,其中57例(25.45%)为CRPA-BSI,167例(74.55%)为碳青霉烯敏感铜绿假单胞菌血流感染(CSPA-BSI);血流感染前使用免疫抑制剂、全肠外营养、头孢菌素类、碳青霉烯类、氟喹诺酮类、抗真菌类、糖肽类、抑酸剂均增加CRPA-BSI风险(P<0.05)。结论 CRPA-BSI的相关危险因素分析为医院感染的预防和控制提供了一定的参考依据。Objective To determine the clinical characteristics,risk factors and treatment outcomes of carbapenem-resistant Pseudomonas aeruginosa bloodstream infection(CRPA-BSI).Methods Clinical data of patients with PA-BSI in a class-A teaching hospital from 2010 to 2019 were retrospectively analyzed.The risk factors of CRPA-BSI were analyzed by univariate and Logistic regression.Results Totally 224 patients with PA-BSI were included,of which 57(25.45%)were CRPA-BSI,while 167(74.55%)were carbapenem-sensitive Pseudomonas aeruginosa bloodstream infections(CSPA-BSI).Exposure to immunosuppressive agents,total parenteral nutrition,cephalosporins,carbapenems,fluoroquinolones,antifungals,glycopeptides and acid inhibitors all increased risks to carbapenem-resistant Pseudomonas aeruginosa infection(P<0.05).Conclusion The risk factors of CRPA-BSI provide a certain reference for the prevention and control of nosocomial infection.
关 键 词:耐碳青霉烯铜绿假单胞菌 血流感染 危险因素
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