鼓膜穿刺术+地塞米松磷酸钠注射液鼓室冲洗对分泌性中耳炎患者听力恢复的影响  

Effects of auripuncture and dexamethasone sodium phosphate injection tympanic cavity irrigation on hearing recovery in patients with secretory otitis media

作　　者：吕唯 LYU Wei(Department of Otolaryngology,People’s Hospital of Buyi and Miao Autonomous Prefecture,Xingyi 562400,China)

机构地区：[1]贵州省布依族苗族自治州人民医院耳鼻咽喉科,562400

出　　处：《中国实用医药》2020年第17期12-15,共4页China Practical Medicine

摘　　要：目的探讨鼓膜穿刺术+地塞米松磷酸钠注射液鼓室冲洗对分泌性中耳炎(SOM)患者的影响。方法100例SOM患者,根据治疗方法的不同分为研究组(52例)与对照组(48例)。对照组接受鼓膜穿刺术治疗,研究组接受鼓膜穿刺术+地塞米松磷酸钠注射液鼓室冲洗治疗。比较两组疗效、治疗前后听觉阈值、血清炎症因子[白介素-6(IL-6)、白介素-10(IL-10)、内皮素-1(ET-1)]、免疫功能指标(CD3^+、CD4^+)、1年内SOM复发率。结果研究组治疗总有效率92.31%(48/52)高于对照组77.08%(37/48),差异有统计学意义(χ^2=4.538,P=0.033<0.05)。治疗1个月后,研究组500、1000、2000 Hz下听觉阈值水平分别为(8.12±1.31)、(5.12±1.34)、(6.26±1.51)dB,优于对照组的(11.74±2.01)、(8.49±1.15)、(9.34±2.03)dB,差异有统计学意义(P<0.05);研究组血清IL-6、IL-10、ET-1水平低于对照组,差异有统计学意义(P<0.05);研究组CD3^+、CD4^+水平均高于对照组,差异有统计学意义(P<0.05)。研究组1年内SOM复发率5.77%(3/52)低于对照组20.83%(10/48),差异有统计学意义(χ^2=5.008,P=0.025<0.05)。结论鼓膜穿刺术+地塞米松磷酸钠注射液鼓室冲洗治疗SOM,疗效确切,能提高患者听力水平,降低复发率,还可以降低炎性因子表达水平,提高免疫功能。Objective To discuss the effect of auripuncture and dexamethasone sodium phosphate injection tympanic cavity irrigation on hearing recovery in patients with secretory otitis media(SOM).Methods A total of 100 SOM patients were divided into research group(52 cases)and control group(48 cases)by different treatment methods.The control group was treated by auripuncture,and the research group was treated by auripuncture and dexamethasone sodium phosphate injection tympanic cavity irrigation.The clinical efficacy,auditory threshold,serum inflammatory factors[interleukin-6(IL-6),interleukin-10(IL-10),endothelin-1(ET-1)],immune function(CD3^+,CD4^+)before and after treatment,and recurrence of SOM within 1 year were compared between the two groups.Results The total effective rate of treatment 92.31%(48/52)of the research group was higher than that of the control group 77.08%(37/48),and the difference was statistically significant(χ^2=4.538,P=0.033<0.05).1 month after treatment,auditory threshold levels at 500,1000,2000 Hz of the research group were(8.12±1.31),(5.12±1.34)and(6.26±1.51)dB respectively,which were all better than those of the control group(11.74±2.01),(8.49±1.15)and(9.34±2.03)dB,and the difference was statistically significant(P<0.05).The levels of serum IL-6,IL-10 and ET-1 of the research group were lower than those of the control group,and the difference was statistically significant(P<0.05).The levels of CD3^+and CD4^+of the research group were higher than those of the control group,and the difference was statistically significant(P<0.05).The recurrence rate of SOM within 1 year 5.77%(3/52)of the research group was lower than that of the control group 20.83%(10/48),and the difference was statistically significant(χ^2=5.008,P=0.025<0.05).Conclusion Auripuncture and dexamethasone sodium phosphate injection tympanic cavity irrigation shows affirmative efficacy for the treatment of SOM,which can improve hearing level of patients,reduce the recurrence rate,but also reduce the expression level of inflamma

关 键 词：鼓膜穿刺术 地塞米松磷酸钠注射液 鼓室冲洗 分泌性中耳炎 听觉阈值 

分 类 号：R764.21[医药卫生—耳鼻咽喉科]