日常膳食锌摄入水平与绝经后女性骨密度之间的关系:一项基于DRYAD数据库的二次分析  

Relationship between daily dietary zinc intake and bone mineral density of postmenopausal women:A secondary analysis based on the DRYAD database

作　　者：倪佳 王芳 王皓 NI Jia;WANG Fang;WANG Hao(Center for Reproductive Medicine,Luoyang Central Hospital Affiliated to Zhengzhou University,Luoyang 471000;Department of Cardiology,Luoyang Central Hospital Affiliated to Zhengzhou University,Luoyang 471000,China)

机构地区：[1]郑州大学附属洛阳中心医院生殖医学中心,河南洛阳471000 [2]郑州大学附属洛阳中心医院心内科,河南洛阳471000

出　　处：《中国骨质疏松杂志》2020年第7期1001-1004,共4页Chinese Journal of Osteoporosis

摘　　要：目的明确每日膳食锌摄入量与绝经后女性骨密度之间的相关性。方法采用Empowerstats和R软件对DRYAD数据库数据进行二次分析,通过线性回归探索每日膳食锌摄入量与绝经后女性骨密度之间的线性关系,并采用广义加性模型进行曲线拟合分析二者间的非线性关系。结果该研究共纳入282例绝经后女性。在调整年龄、每日钙摄入量后,每日膳食锌摄入量和绝经后女性髋骨骨密度存在阈值关联。当每日摄入锌超过32.9 mg时,每日锌摄入量每增加1 mg,髋骨骨密度增加4.87 mg/cm^2(P<0.05)。结论每日膳食锌摄入量与绝经后女性骨密度之间存在阈值效应关系,这将为今后绝经后女性预防骨质疏松的营养支持与补充提供依据和指导。Objective To identify the correlation between daily dietary zinc intake and bone mineral density in postmenopausal women.Methods The Empowerstats and R software were used for secondary analysis of DRYAD database data.Linear regression was used to explore the linear relationship between daily dietary zinc intake and bone mineral density in postmenopausal women,and generalized additive model was used for curve fitting analysis of the non-linear relationship.Results The study contains 282 cases of postmenopausal women.After adjusting for age and daily calcium intake,there was a threshold relationship between daily dietary zinc intake and bone mineral density of the hip in postmenopausal women.When the daily intake of zinc exceeded 32.9 mg,every 1 mg increase in daily zinc intake,the hip bone mineral density increased by 4.87 mg/cm^2(P<0.05).Conclusion There is a threshold effect relationship between daily dietary zinc intake and bone mineral density in postmenopausal women,which may provide fundamental information and valuable guidance for future nutritional support and supplementation in postmenopausal women to prevent osteoporosis.

关 键 词：锌 骨密度 绝经后女性 骨质疏松 

分 类 号：R683.3[医药卫生—骨科学]