槲皮素对双膦酸盐治疗老年性骨质疏松患者骨代谢指标改善效果的分析  

Effect of quercetin supplementation on bone metabolism in elderly osteoporosis patients treated with bisphosphonates

作　　者：刘军[1] 刘峰 闫楚奇 朱耿耀 王海侠[1] LIU Jun;LIU Feng;YAN Chuqi;ZHU Gengyao;WANG Haixia(Xuzhou Central Hospital,Xuzhou 221000,China)

机构地区：[1]徐州市中心医院,江苏徐州221000

出　　处：《中国骨质疏松杂志》2020年第7期1044-1048,共5页Chinese Journal of Osteoporosis

摘　　要：目的观察槲皮素对双膦酸盐类治疗老年性骨质疏松患者骨代谢指标的影响。方法 216例老年性骨质疏松患者(收治时间:2017年1月至2018年1月)以信封随机分组法分为常规对照组(共108例,双膦酸盐+骨健康补充剂治疗6个月)和槲皮补充组(共108例,以双膦酸盐+骨健康补充剂+槲皮素治疗6个月)。分析常规对照组和槲皮补充组的主客观疗效(总有效率、ODI评分、SF-36评分及VAS视觉评分)、骨密度及骨代谢指标(CTX-1、BALP、BGP、t PINP、PTH)的差异。结果与治疗前比较,槲皮补充组和常规对照组治疗后的前臂远端骨密度、BALP及SF-36评分均提升,而VAS评分、ODI评分、PTH、BGP、CTX-1、t PINP均下降(P均<0.05),但槲皮补充组前臂远端骨密度、BALP及SF-36评分的升幅更大,VAS评分、ODI评分、PTH、BGP、CTX-1、t PINP的降幅更大。槲皮补充组临床总有效率(87.04%)显著优于常规对照组(68.52%)(P<0.05)。结论补充槲皮素辅助双膦酸盐治疗老年性骨质疏松患者,可显著改善患者骨密度指标、疼痛症状、功能障碍情况及骨代谢指标的异常表达,提升患者生活质量。Objective To observe the effect of quercetin on bone metabolism in osteoporotic elderly patients treated with bisphosphonates.Methods Two hundred and sixteen senile patients with osteoporosis(admission time:2017.1-2018.1)were divided into routine control group(108 cases,treated with bisphosphonates+bone health supplement for 6 months)and quercetin supplement group(108 cases,treated with bisphosphonates+bone health supplement+quercetin for 6 months).The differences of subjective and objective efficacy(total effective rate,ODI score,SF-36 score,and VAS visual score),bone mineral density,and bone metabolic index(CTX-1,BALP,BGP,t PINP,PTH)between the conventional control group and quercetin supplement group were analyzed.Results Compared with those before the treatment,BMD,BALP,and SF-36 scores of the distal forearm in both quercetin supplementation group and conventional control group increased,while VAS,ODI score,and bone metabolic index(PTH,BGP,CTX-1,t PINP)decreased(all P<0.05).BMD,BALP,and SF-36 of the distal forearm in quercetin supplementation group increased more(all P<0.05),and VAS,ODI,and bone metabolism index(PTH,BGP,CTX-1,t PINP)decreased more.The total clinical effective rate of quercetin supplementation group(87.04%)was significantly better than that of routine control group(68.52%,P<0.05).Conclusion Quercetin supplementation can significantly relieve the abnormal level of bone mineral density,pain symptom,dysfunction,and bone metabolism in elderly patients with osteoporosis,and improve the quality of life of the patients.

关 键 词：槲皮素 维生素D3 降钙素 双膦酸盐 骨质疏松 骨代谢 

分 类 号：R589.5[医药卫生—内分泌] R969.2[医药卫生—内科学]