萆薢分清丸联合克拉霉素治疗ⅢA型前列腺炎的临床研究  

Clinical study on Bixie Fenqing Pills combined with clarithromycin in treatment of type ⅢA prostatitis

作　　者：张晓会 刘乃胜[1] 毛俊月 李晓蒙 易虎[2] ZHANG Xiao-hui;LIU Nai-sheng;MAO Jun-yue;LI Xiao-meng;YI Hu(Department of Urology,Dongli Hospital Dongli District,Tianjin 300300,China;Department of Urology,the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China)

机构地区：[1]天津市东丽区东丽医院泌尿外科,天津300300 [2]天津中医药大学第一附属医院泌尿外科,天津300193

出　　处：《现代药物与临床》2020年第6期1111-1116,共6页Drugs & Clinic

基　　金：天津市卫生和计划生育委员会科研基金项目(2017KZ059)。

摘　　要：目的探讨萆薢分清丸联合克拉霉素治疗ⅢA型前列腺炎的临床效果。方法选取2018年6月—2019年12月天津市东丽区东丽医院收治的154例ⅢA型前列腺炎患者,随机分为对照组和治疗组,每组各77例。对照组口服克拉霉素片,0.25 g/次,2次/d。治疗组在对照组基础上口服萆薢分清丸,6 g/次,2次/d。两组均连续治疗4周。比较两组临床疗效,观察两组慢性前列腺炎症状指数(NIH-CPSI)评分、排尿日记相关指标、前列腺按摩液(EPS)中白细胞(WBC)数量及肿瘤坏死因子(TNF)-α、白介素(IL)-8、巨噬细胞炎性蛋白(MIP)-1α、基质金属蛋白酶(MMP)-9、C反应蛋白(CRP)水平的变化情况。结果治疗后,治疗组总有效率是94.8%显著高于照组84.4%(P<0.05)。两组治疗后NIH-CPSI中各部分(疼痛或不适症状、排尿症状、生活质量3个部分)评分及总评分均显著低于本组治疗前(P<0.05);但治疗组NIH-CPSI各评分比对照组的改善均更显著(P<0.05)。两组治疗后尿急次数、日间和夜间排尿次数均显著减少(P<0.05),但平均排尿量均显著增加(P<0.05);且治疗后,治疗组以上排尿日记相关指标较同期对照组的改善均更显著(P<0.05)。治疗后,两组EPS中WBC数量、TNF-α、IL-8、MIP-1α、MMP-9和CRP水平均显著降低(P<0.05);且治疗后,治疗组这些EPS检查指标较同期对照组显著更低(P<0.05)。结论萆薢分清丸联合克拉霉素治疗ⅢA型前列腺炎具有确切的临床疗效,对患者的骨盆生殖区域疼痛或不适、排尿异常和生活质量均有明显改善作用,具有一定的临床推广应用价值。Objective To explore the clinical effect of Bixie Fenqing Pills combined with clarithromycin in treatment of type ⅢA prostatitis. Methods A total of 154 patients with type ⅢA prostatitis admitted to Dongli Hospital Dongli District from June 2018 to December 2019 were randomly divided into control group(n=77) and treatment group(n=77). The control group was po administered with Clarithromycin Tablets, 0.25 g/time, twice daily. The treatment group was po administered with Bixie Fenqing Pills on the basis of the control group, 6 g/time, twice daily. All patients were treated for 4 weeks. The clinical efficacy in two groups were compared, and the changes of NIH-CPSI score, indicators related to urination diary, WBC amount, TNF-α, IL-8, MIP-1α, MMP-9, and CRP in prostate massage fluid(EPS) were compared between the two groups. Results After treatment, the total effective rate of the treatment group was 94.8%, which was significantly higher than that of the control group(84.4%)(P < 0.05). The scores of pain or discomfort symptoms, urination symptoms, life quality and the total scores of NIH-CPSI scores in two groups after treatment were significantly lower than those before treatment(P < 0.05). However, the improvement of NIH-CPSI scores in the treatment group was more significant than that in the control group(P < 0.05). After treatment, the times of urination urgency, daytime and night urination were significantly reduced in both groups(P < 0.05), but the average urination volume was significantly increased in both groups(P < 0.05). After treatment, the improvement of urinary diary related indexes in the treatment group was more significant than that in the control group(P < 0.05). After treatment, WBC amount, TNF-α, IL-8, MIP-1α, MMP-9, and CRP levels in EPS in both groups were significantly reduced(P < 0.05). After treatment, these EPS indicators were significantly lower in the treatment group than in the control group(P < 0.05). Conclusion Bixie Fenqing Pills combined with clarithromycin has definite clini

关 键 词：萆薢分清丸 克拉霉素片 ⅢA型前列腺炎 慢性前列腺炎症状指数 排尿日记相关指标 前列腺按摩液 

分 类 号：R976[医药卫生—药品]