中国妇女使用MCu375与TCu380A宫内节育器效果的meta分析  

Meta-analysis of the effect of MCu375 IUD and TCu380A IUD used in China

作　　者：张敏[1] 张学宁[1] 周健[1] 巴磊[1] 林洁[1] 杨月华[1] 施雯慧[1] 孙志明[1] ZHANG Min;ZHANG Xuening;ZHOU Jian;BA Lei;LIN Jie;YANG Yuehua;SHI Wenhui;SUN Zhiming(Jiangsu Insitute of Planned Parenthood Research/NHFPC Center for Contraceptives Adverse Reactor Surveillance,Nanjing,Jiangsu Province,210036)

机构地区：[1]江苏省计划生育科学技术研究所,国家卫生人口计生委计划生育药具不良反应监测中心,南京210036

出　　处：《中国计划生育学杂志》2020年第7期972-976,共5页Chinese Journal of Family Planning

基　　金：江苏省委妇幼健康重点人才(FRC201756);江苏省卫计委科教课题(H201616);江苏省卫生健康委科研课题(H2018095);江苏省卫健委指导课题(Z2017003);江苏省青年医学重点人才项目(QNRC2016555);江苏省妇幼健康科研项目资助(F201760)。

摘　　要：目的:系统性评估中国妇女使用MCu375与TCu380A宫内节育器(IUD)的安全性和有效性。方法:电子检索各文献库从建库至2018年12月国内外发表的涉及MCu375与TCu380A IUD的随机对照或类随机对照研究,使用Endnote x7及RevMan5.3.3软件筛选、评估和综合分析文献。结果:共纳入13篇合格文献,妇女使用IUD第6,12,24个月MCu375的意外妊娠率高于TCu380A,RR(95%CI)分别为6.96(1.59~30.50),1.95(1.51~2.53)和1.90(1.16~3.13);第6,12个月的脱落率高于TCu380A,RR(95%CI)分别为2.40(1.29~4.47),2.51(2.09~3.01),均有统计学差异。第6,12,24个月的因症终止率两种IUD的差异无统计学意义。结论:中国妇女使用MCu375的妊娠率高于TCu380A。Objective:To compare the effectiveness and safety of MCu375 intrauterine device(IUD) and TCu380 A IUD used in China. Methods:Electronic search was used to identify the literatures about the clinical effect and safety of MCu375 IUD and TCu380 A IUD in different database from the construction of the database until December 2018, which included the randomized controlled trials(RCT) and quasi-RCT. The literatures were screened, evaluated, and synthesis analyzed by Endnote x7 and RevMan5.3.3 software. Results: Thirteen studies were included in this Meta analysis. The cumulative pregnancy rates of MCu375 IUD in 6 months, 12 months and 24 months after inserted were significant higher than those of TCu380 A IUD, which’s RR(95%CI) were 6.96(1.59-30.50),1.95(1.51-2.53), and 1.90(1.16-3.13). The expulsion rates of MCu375 IUD in 6 months and 12 months after inserted were significant different from those of TCu380 A IU, which’s RR(95%CI) were 2.40(1.29-4.47) and 2.51(2.09-3.01). The cumulative medical removal rates of MCu375 IUD in 6 months, 12 months and 24 months after inserted had no significant different from those of TCu380 A IUD. Conclusion: The rate of pregnancy of MCu375 IUD used is higher than that of TCu380 A IUD used in China.

关 键 词：宫内节育器 MCu375 TCU380A META分析 

分 类 号：R169.41[医药卫生—公共卫生与预防医学]